The principle of pretargeted radioimmunoimaging and therapy has been investigated over
the past 30 y in preclinical and clinical settings with the aim of reducing the radiation burden …

Pretargeted radioimmunodiagnosis and radioimmunotherapy aim to efficiently combine
antitumor antibodies and medicinal radioisotopes for high-contrast imaging and high …

In vivo pretargeting stands as a promising approach to harnessing the exquisite tumor-
targeting properties of antibodies for nuclear imaging and therapy while simultaneously …

To enhance the therapeutic efficacy of radioimmunotherapy of cancer, several pretargeting
strategies have been developed. In pretargeted radioimmunotherapy, the tumor is …

This article reviews recent preclinical and clinical advances in the use of pretargeting
methods for the radioimmunodetection and radioimmunotherapy of cancer. Whereas directly …

Selective delivery of radionuclides to tumors may be accomplished using a two-step
approach, in which in the first step the tumor is pretargeted with an unlabeled antibody …

Background Oncological pretargeting has been implemented and tested in several different
ways in preclinical models and clinical trials over more than 30 years. Despite highly …

Labeled antibodies, as well as their fragments and antibody-derived recombinant constructs,
have long been proposed as general vectors to target radionuclides to tumor lesions for …

Pretargeted radioimmunotherapy (PRIT) was evaluated using an antibody-
streptavidinconjugate, followed by a biotin-galactose humanserumalbuminclearingagentand …

During the past two decades, considerable research has been devoted to radionuclide
therapy using radiolabeled monoclonal antibodies and receptor binding agents …