Measurement of the proportion of serotonin 1A receptors configured in high affinity state: A comparison PET study using agonist radioligand [11C] CUMI-101 and …
VJ Majo, J Prabhakaran, M Millak, L Savenkova… - 2009 - Soc Nuclear Med
1222 Objectives [11C] CUMI-101 is a 5-HT 1A receptor agonist tracer suitable to image 5-HT
1A receptors configured in high affinity state. In this study, in vivo binding of [11C] CUMI-101 …
1A receptors configured in high affinity state. In this study, in vivo binding of [11C] CUMI-101 …
In vivo quantification of human serotonin 1A receptor using 11C-CUMI-101, an agonist PET radiotracer
MS Milak, C DeLorenzo, F Zanderigo… - Journal of Nuclear …, 2010 - Soc Nuclear Med
The serotonin (5-hydroxytryptamine, or 5-HT) type 1A receptor (5-HT1AR) is implicated in
the pathophysiology of numerous neuropsychiatric disorders. We have published the initial …
the pathophysiology of numerous neuropsychiatric disorders. We have published the initial …
Effect of fenfluramine on 5-HT1B binding of [11C] AZ10419369 in the primate brain
489 Objectives We recently reported an initial PET-study using the selective serotonin 5-HT
1B receptor radioligand [11 C] AZ10419369. The 5-HT 1B receptor has a role in the …
1B receptor radioligand [11 C] AZ10419369. The 5-HT 1B receptor has a role in the …
In vivo receptor occupancy using [N-methyl-3H3] AZ10419369, a serotonin 5HT1B receptor radiotracer
D Maier, M Ding, C Sobotka-Briner, A Medd, M Powell… - 2008 - Soc Nuclear Med
905 Objectives: Radiotracer tools suitable for PET studies often serve as preclinical tools for
in vivo receptor occupancy. AZ10419369 has sub-nM affinity for the 5-HT1B receptor and …
in vivo receptor occupancy. AZ10419369 has sub-nM affinity for the 5-HT1B receptor and …
Selectivity in rodents and monkeys of 11C-CUMI-101, an agonist radioligand for serotonin 5-HT1A receptors
JS Liow, S Lu, S Zoghbi, S Shrestha, R Gladding… - 2010 - Soc Nuclear Med
164 Objectives 11C-CUMI-101 is an agonist radioligand for the serotonin subtype 1A (5-
HT1A) receptor. Since some 5-HT1A receptor agonists also have significant affinity for alpha …
HT1A) receptor. Since some 5-HT1A receptor agonists also have significant affinity for alpha …
Modeling considerations for 11C-CUMI-101, an agonist radiotracer for imaging serotonin 1A receptor in vivo with PET
Several lines of evidence demonstrate involvement of serotonin 1A receptors (5-HT1ARs) in
the pathophysiology of neuropsychiatric disorders such as depression, suicidal behavior …
the pathophysiology of neuropsychiatric disorders such as depression, suicidal behavior …
Evaluation of [11C] CIMBI-5 as a 5-HT2A receptor agonist PET tracer in non-human primates
J Prabhakaran, V Majo, M Milak, N Gillings, A Ettrup… - 2012 - Soc Nuclear Med
1876 Objectives In vivo PET studies of the 5-HT2A receptor have largely been limited to
antagonist radiotracers, and antagonists do not distinguish high and low affinity agonist …
antagonist radiotracers, and antagonists do not distinguish high and low affinity agonist …
Modeling serotonin 1A receptors in baboon and human subjects using the agonist tracer [11C] CUMI-101 and positron emission tomography
Methods PET scans were performed in male baboons (Papio anubis) and healthy human
volunteers with an ECAT EXACT HR+ scanner.[11 C] CUMI-101 (15.0±3.0 mCi, SA= 1.3±0.2 …
volunteers with an ECAT EXACT HR+ scanner.[11 C] CUMI-101 (15.0±3.0 mCi, SA= 1.3±0.2 …
Test–retest reliability of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
M Nord, SJ Finnema, M Schain, C Halldin… - European journal of …, 2014 - Springer
Abstract Purpose [11 C] AZ10419369 is a recently developed 5-HT 1B receptor radioligand
that is sensitive to changes in endogenous serotonin concentrations in the primate brain …
that is sensitive to changes in endogenous serotonin concentrations in the primate brain …
Quantification of [11C] CUMI-101, an agonist radiotracer for imaging the 5-HT1A receptor in vivo with positron emission tomography
904 Objectives: Several lines of evidence demonstrate involvement of 5-HT1A receptors in
the pathophysiology of major neuropsychiatric disorders such as depression, suicidal …
the pathophysiology of major neuropsychiatric disorders such as depression, suicidal …