RESULTS Sf9 insect ovarian cells were infected with a recombinant baculovirus carryingthe
human MDR1 eDNA which had been constructed and characterizedpreviously (18). Unin …

Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health,
Bethesda, Maryland 20892 Received September 8, 1989; Revised Manuscript Received …

The development of multidrug resistance (MDR) is associated with the overproduction of a
plasma membrane glycoprotein, P glycoprotein. Here we report the functional expression of …

Multidrug resistance (MDR) in mammalian cells is associated with the expression of the
MDR1 gene encoding P-glycoprotein (P-gp), an and active efflux pump for various lipophilic …

In multidrug resistance, cells become simultaneously resistant to anthracyclines, vinca
alkaloids, epipodophyllotoxins, and certain other natural product cytotoxic drugs. Resistance …

We have constructed a retrovirus expression vector that carries the murine mdr cDNA
transcribed under the control of the human H4 histone promoter to examine the feasibility of …

A full-length cDNA for the human multidrug resistance gene 1 (MDR1) has been inserted
into a retroviral vector containing a murine Harvey sarcoma virus from which the viral …

We have found cDNAs corresponding to a novel human P‐glycoprotein gene in liver cDNA
banks. The sequence of the 3′ part of this cDNA reveals a domainal organization of the …

P-glycoprotein (Pgp) is an ABC (ATP binding cassette) transporter that is often
overexpressed in tumours, contributing significantly to their multidrug resistance. In this …

Transfer of the human multidrug resistance 1 (MDR1) gene to hematopoietic stem cells
offers an approach to overcome the myelosuppression caused by a number of …