Safety, biodistribution, and radiation dosimetry of 18F-rhPSMA-7.3 in healthy adult volunteers

T Tolvanen, K Kalliokoski, S Malaspina… - Journal of Nuclear …, 2021 - Soc Nuclear Med
This first-in-humans study investigated the safety, biodistribution, and radiation dosimetry of
a novel 18F-labeled radiohybrid prostate-specific membrane antigen (rhPSMA) PET …

Radiation dosimetry and biodistribution of 18F-PSMA-11 for PET imaging of prostate cancer

S Piron, K De Man, N Van Laeken… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is highly overexpressed in prostate cancer.
Many PSMA analog radiotracers for PET/CT prostate cancer staging have been developed …

Quantitative and qualitative analyses of biodistribution and PET image quality of a novel radiohybrid PSMA, 18F-rhPSMA-7, in patients with prostate cancer

SW Oh, A Wurzer, EJ Teoh, S Oh… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Radiohybrid PSMA (rhPSMA) ligands, a new class of theranostic prostate-specific
membrane antigen (PSMA)–targeting agents, feature fast 18F synthesis and utility for …

[HTML][HTML] Kinetic analysis and optimisation of 18F-rhPSMA-7.3 PET imaging of prostate cancer

S Malaspina, V Oikonen, A Kuisma, O Ettala… - European Journal of …, 2021 - Springer
Purpose This phase 1 open-label study evaluated the uptake kinetics of a novel theranostic
PET radiopharmaceutical, 18 F-rhPSMA-7.3, to optimise its use for imaging of prostate …

Uptake of 18F-rhPSMA-7.3 in Positron Emission Tomography Imaging of Prostate Cancer: A Phase 1 Proof-of-Concept Study

S Malaspina, P Taimen, M Kallajoki… - Cancer Biotherapy & …, 2022 - liebertpub.com
Background: This study evaluated tracer uptake and lesion detectability with the novel
radiopharmaceutical 18F-radiohybrid (rh) PSMA-7.3 in patients with prostate cancer (PCa) …

Comparison of internal dosimetry of 18F-PSMA-1007 and 68Ga-PSMA-11-HBED-CC

P Sharma, A Watts, H Singh - Clinical Nuclear Medicine, 2022 - journals.lww.com
Background Prostate cancer (PCa) is the most common cancer in men worldwide. Targeting
prostate-specific membrane antigen (PSMA) using radiopharmaceuticals has shown …

Phase I/IIa trial of 18F-prostate specific membrane antigen (PSMA) 1007 PET/CT in healthy volunteers and prostate cancer patients

U Tateishi, K Kimura, J Tsuchiya, D Kano… - Japanese Journal of …, 2024 - academic.oup.com
Objective 18F-PSMA 1007 is a promising PET tracer for prostate cancer. We aimed to
examine the safety, biodistribution, radiation dosimetry, and clinical effectiveness in …

[HTML][HTML] Preclinical biodistribution and dosimetry and human biodistribution comparing 18F-rhPSMA-7 and single isomer 18F-rhPSMA-7.3

K Knorr, SW Oh, M Krönke, A Wurzer, C D'Alessandria… - EJNMMI research, 2022 - Springer
Background Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands such as
18F-rhPSMA-7 are a new class of theranostic agents in clinical development for prostate …

Comparative preclinical biodistribution, dosimetry, and endoradiotherapy in metastatic castration-resistant prostate cancer using 19F/177Lu-rhPSMA-7.3 and 177Lu …

N Yusufi, A Wurzer, M Herz… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands are applicable as
radiochemical twins for both diagnostic PET imaging and endoradiotherapy. On the basis of …

[HTML][HTML] Intra-individual dynamic comparison of 18F-PSMA-11 and 68Ga-PSMA-11 in LNCaP xenograft bearing mice

S Piron, J Verhoeven, B Descamps, K Kersemans… - Scientific reports, 2020 - nature.com
Recently, a 18F-labeled derivative of the widely used 68Ga-PSMA-11 was developed for
PET imaging of prostate cancer. Although 18F-PSMA-11 has already been evaluated in a …