To visualize the adenylate cyclase (AC)-related second messenger system,[11C]
forskolin,[11C] 1-acetyl-7-deacetylforskolin,[11C] 1, 9-dideoxyforskolin and [11C] 1 …

We prepared two fluorine containing carbamate analogs of forskolin as potential agents for
imaging adenylyl cyclase in the living brain with positron emission tomography. Both …

Labeled and unlabeled 1-acetyl-7-deacetylforskolin and forskolin were synthesized by
acetylation of 7-deacetylforskolin with labeled and unlabeled acetyl chloride. The binding of …

The binding sites for a radiolabeled form of the potent activator of adenylate cyclase,
forskolin, have been localized in the rat brain, pituitary and spinal cord. Using the …

Abstract Radiolabeled forskolin, 7-(3 H-acetyl)-forskolin, was synthesized to explore
interactions between forskolin and bovine brain membrane preparations. The radiolabeled …

Abstract Using [3 H] 14, 15-dihydroforskolin as a radioactive ligand, forskolin binding sites in
rat liver and rat brain membranes were identified. Scatchard analysis of binding data …

The diterpine forskolin is a potent stimulator of brain adenylate cyclase (Seamon et al.,
1981). The mechanism for this action appears to involve both a direct activation of the …

(2-Aminoethyl) aminocarbonyl-7-desacetyfforskolin(7-AEC-Fsk) and 6-(2-aminoethyl)
aminocarbonylforskolin(6-AEC-Fsk) were synthesized and tested for their ability to activate …

Two radioiodinated derivatives of forskolin,[125 I] 6-IHPP-Fsk and [125 I] 7-IHPP-Fsk, were
synthesized as specific ligands for adenylyl cyclase and glucose transporter …

Three series of analogs were regioselectively prepared from a protected forskolin precursor
to afford 7-carbamoyl-7-desacetylforskolins (series 1), 6-carbamoyl-7-desacetylforskolins …