1469 Objectives: There is a growing body of evidence suggesting the link between the
cognitive decline and the cholinergic dysfunction. The purpose of this study was to reveal …

1548 Introduction: Normal aging has multiple effects on brain including morphologic,
functional and metabolic changes. Recently, principal components analysis (PCA) has been …

1529 Objectives: The nucleus basalis of Meynert (NbM), primary cholinergic source of
neurons, is hypothesized to be the origin of Alzheimer's disease (AD) pathology. The impact …

Olfactory dysfunction is an early feature of Alzheimer disease. This study used multimodal
imaging of PET and 18F-FDG combined with diffusion tensor imaging (DTI) to investigate the …

Background: Cholinergic dysfunction plays an important role in mild cognitive impairment
(MCI). The basal nucleus of Meynert (BNM) provides the main source of cortical cholinergic …

1570 Objectives: The question whether dementia with Lewy bodies (DLB) and Parkinson's
Disease (PD) with cognitive impairment are the same disorder has been debated for …

Purpose The purpose of the study was the identification of group and individual subject
patterns of cerebral glucose metabolism (CMRGlu) in patients with Alzheimer's disease (AD) …

Introduction Metabolic brain network analysis based on graph theory using FDG PET
imaging is potentially useful for investigating brain activity alternation due to metabolism …

Evaluating the symptomatic progression of mild cognitive impairment (MCI) caused by
Alzheimer disease (AD) is practically accomplished by tracking performance on cognitive …

2503 Introduction: To explore the metabolic network attributes related to cognitive
impairment in Parkinson9s disease (PD), a preliminary study based on graph theory network …