CardioPET, a potential PET tracer for coronary artery disease, exhibits higher heart-to-liver ratios in fed mice and rats

T Shoup, D Elmaleh, E Carter, D Winter, C Tolman… - 2009 - Soc Nuclear Med
1933 Objectives CardioPET (trans-9-[18 F] fluoro-3, 4-methyleneheptadecanoic acid), a
modified fatty acid closely resembling naturally-occurring free fatty acids, undergoes …

Comparison of uptake of CardioPET, a potential PET tracer for myocardial fatty acid utilization and BFPET, a possible PET blood flow marker in fed vs fasted mice

E Carter, D Elmaleh, T Shoup, A Bonab, K Paul… - 2011 - Soc Nuclear Med
1098 Objectives CardioPET (trans-9-[18F] fluoro-3, 4-methyleneheptadecanoic acid), a
modified fatty acid closely resembling naturally-occurring free fatty acids, undergoes …

A phase I study evaluating myocardial pharmacokinetic behavior of CardioPET, a new cardiac PET tracer, in normal subjects and subjects with stable coronary artery …

A Kardan, T Shoup, S Barrow, S Dragotakes… - 2008 - Soc Nuclear Med
834 Objectives: CardioPET (trans-9-[18 F] fluoro-3, 4-methyleneheptadecanoic acid), a
modified fatty acid closely resembling naturally occurring fatty acids, undergoes metabolic …

Biodistribution of CardioPET as a PET tracer for estimating and differentiating fat deposit function in mice

E Carter, T Shoup, D Winter, C Tolman, D Elmaleh… - 2008 - Soc Nuclear Med
1292 Objectives: To evaluate the uptake behavior of CardioPET in brown and white fat in
rats and in fed and fasted mice. In contrast to other species, adult mice keep brown fat …

A phase I study to evaluate the safety and biodistribution of CardioPET as a new cardiac PET tracer: Studies in normal subjects

A Kardan, T Shoup, S Barrow, S Dragotakes… - 2008 - Soc Nuclear Med
278 Objectives: CardioPET (trans-9-[18 F] fluoro-3, 4-methyleneheptadecanoic acid) is a
modified fatty acid closely resembling naturally occurring fatty acids (FFAs). FFAs are the …

Synthesis and preliminary evaluation of an 18F-labeled oleic acid analog for PET imaging of fatty acid uptake and metabolism

Z Cai, NS Mason, CJ Anderson, WB Edwards - Nuclear medicine and …, 2016 - Elsevier
Introduction Imaging fatty acid uptake and utilization has broad impact in investigating
myocardial diseases, hepatic functions, tumor progression, and the metabolic state of …

Modified Synthesis and Assessment of 18F-FTP for Cardiac Ischemia/Reperfusion Injury in Rats

T Gu - 2020 - Soc Nuclear Med
1386 Introduction: PET fatty acid tracers have the ability to reflect myocardial β-oxidation.
Specifically, ischemic myocardium metabolizes glucose preferentially, with reduced MFAO …

Evaluation of trans-9-18F-fluoro-3, 4-Methyleneheptadecanoic acid as a PET tracer for myocardial fatty acid imaging

TM Shoup, DR Elmaleh, AA Bonab… - Journal of Nuclear …, 2005 - Soc Nuclear Med
This study describes the radiosynthesis and preliminary biologic evaluation of trans-9 (RS)-
18F-fluoro-3, 4 (RS, RS)-methyleneheptadecanoic acid (18F-FCPHA) as a new potential …

Synthesis and preliminary evaluation of 18F-labeled 4-thia palmitate as a PET tracer of myocardial fatty acid oxidation

TR DeGrado, S Wang, JE Holden, RJ Nickles… - Nuclear medicine and …, 2000 - Elsevier
Interest remains strong for the development of a noninvasive technique for assessment of
regional fatty acid oxidation rate in the myocardium. 18F-labeled 4-thia palmitate (FTP, 16 …

Synthesis and preliminary evaluation of 18-[18F] fluoro-4-thia-oleic acid (FTO) as a PET probe of fatty acid oxidation

M Pandey, F Bhattacharyya, A Belanger, S Wang… - 2010 - Soc Nuclear Med
585 Objectives Fatty acid oxidation (FAO) is a major energy providing process with important
implications in cardiovascular, oncologic, neurologic and metabolic diseases. A novel 4-thia …