Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc

TR DeGrado, MK Pandey, JF Byrne… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Abnormalities of zinc homeostasis are indicated in many human diseases. A noninvasive
imaging method for monitoring zinc in the body would be useful to understand zinc …

Imaging zinc trafficking in vivo by positron emission tomography with zinc-62

G Firth, Z Yu, JJ Bartnicka, D Parker, J Kim… - Metallomics, 2022 - academic.oup.com
Non-invasive imaging techniques to dynamically map whole-body trafficking of essential
metals in vivo in health and diseases are needed. Despite 62Zn having appropriate physical …

First PET Imaging Studies With 63Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease

TR DeGrado, BJ Kemp, MK Pandey… - Molecular …, 2016 - journals.sagepub.com
Abnormalities in zinc homeostasis are indicated in many human diseases, including
Alzheimer disease (AD). 63Zn-zinc citrate was developed as a positron emission …

Production of no‐carrier‐added 64Cu from zinc metal irradiated under boron shielding

KR Zinn, TR Chaudhuri, TP Cheng, J Steven Morris… - Cancer, 1994 - Wiley Online Library
Background. Positron emission tomography offers advantages for radioimmunodiagnosis of
cancer but requires radionuclides of appropriate half‐life that have high specific activity and …

Non-standard PET radionuclides: time to get ready for new clinical PET strategies

G Lucignani - European Journal of Nuclear Medicine and Molecular …, 2007 - Springer
Abbas and colleagues from the Institute for Health and Consumer Protection, Joint Research
Centre, European Commission, in Ispra, Italy have recently carried out the production of …

Radiocopper for the imaging of copper metabolism

R Hueting - Journal of Labelled Compounds and …, 2014 - Wiley Online Library
The redox‐active transition metal copper is an essential trace element for growth and
development and serves as a structural or catalytic cofactor for many enzymes in a range of …

Visualization of Copper Metabolism by 64CuCl2-PET

H Wang, X Chen - Molecular imaging and biology, 2012 - Springer
Copper plays an essential role in human physiology. It is required for respiration, radical
defense, neuronal myelination, angiogenesis, and many other processes [1]. At the …

Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography

J Zweit, R Goodall, M Cox, JW Babich… - European journal of …, 1992 - Springer
Clinical utilisation of positron emission tomography could be enhanced by the availability of
shortlived radionuclides derived from generator systems. The zinc-62/copper-62 …

[PDF][PDF] A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals

Y Fujibayashi, K Matsumoto, Y Yonekura… - Journal of nuclear …, 1989 - Soc Nuclear Med
A New Zinc-62/Copper-62 Generator for PET Radiopharmaceuticals Page 1 he zinc-62-copper-62
(62Zn-62Cu)[62Zn:T½= 9.2 hr, 62Cu:T½= 9.8 mm, (1)] generator system is consid ered to …

Insights into trace metal metabolism in health and disease from PET:“PET metallomics”

JJ Bartnicka, PJ Blower - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
Essential trace metals such as copper, zinc, iron, and manganese perform critical functions
in cellular and physiologic processes including catalytic, regulatory, and signaling roles …