Evaluation of serotonin receptors using 18F-trans-Mefway in aging canine model

T Dinh, S Faheem, N Rana, N Saigal, S Pandey… - 2009 - Soc Nuclear Med
1196 Objectives Serotonin 5HT 1A receptors are implicated in neurological and psychiatric
disorders including aging and Alzheimer's disease (AD). We report the in vitro use of 18 F …

18F-Mefway binding to serotonin 5HT1A receptors is reduced in transgenic mouse models of Alzheimer's disease

N Saigal, B Easwaramoorthy, M Nistor, D Do, E Head… - 2007 - Soc Nuclear Med
392 Objectives: Previous work in humans (Kepe, 2005) has shown a 27% hippocampus
(HP) decrease in serotonin 5HT1A receptors in Alzheimer's disease (AD) using 18F-MPPF …

Evaluation of serotonin 5HT1A receptors in postmortem Alzheimer's disease brains

A Bajwa, H Patel, M Pan, C Liang, J Mukherjee - 2013 - Soc Nuclear Med
1791 Objectives Serotonin 5HT 1A receptors may be affected in Alzheimer's disease (AD) by
Aβ-amyloid plaques (Aβ) and neurofibrillary tangles in the hippocampus (HP) and frontal …

Pharmacokinetics of [18F] mefway, a probe for brain serotonin 1A receptor imaging, in rats

BS Kim, JY Choi, EJ Kim, DB Choi, CH Yi, SJ Han… - 2013 - Soc Nuclear Med
1106 Objectives [18F] Mefway has been developed for imaging the serotonin 1A receptors
(5-HT1A) in the brain. This study was conducted to characterize the pharmacokinetics of …

[18F] Mefway is a promising candidate for human use to quantify serotonin 1A receptors

JY Choi, CH Lyoo, KM Kim, KC Lee, YH Ryu - 2016 - Soc Nuclear Med
1863 Objectives Alteration of the serotonin 1A receptor density is strongly implicated in the
neuropsychiatric disorders such as depression, Schizophrenia and anxiety. Although many …

Translational possibility of [18F]Mefway to image serotonin 1A receptors in humans: Comparison with [18F]FCWAY in rodents

JY Choi, BS Kim, CH Kim, DG Kim, SJ Han, K Lee… - Synapse, 2014 - Wiley Online Library
Purpose: To compare the cerebral uptake and binding potential of [18F] FCWAY and [18F]
Mefway in the rodent to assess their potential for imaging serotonin 1A (5‐HT1A) receptors …

3-18F-Mefway, an isomeric analog of mefway for imaging serotonin 5HT1a receptors

J Thio, C Liang, ML Pan, MR Mirbolooki… - 2012 - Soc Nuclear Med
1611 Objectives 18 F-Mefway was developed and evaluated for use as a PET ligand for
imaging 5-HT 1a receptors, a receptor implicated in the study of dementia, anxiety …

18F-Mefway: Efficacy as a PET imaging agent for serotonin 5-HT1A receptors

A Bajwa, A Hillmer, D Wooten, N Saigal, B Christian… - 2014 - Soc Nuclear Med
553 Objectives Serotonin 5-HT 1A receptors, implicated in CNS disorders, have been
studied with 18 F-trans-Mefway (18 F-Mefway) in rodent and nonhuman primate studies …

In vivo evaluation of 18F-MNI698: an 18F-labeled radiotracer for imaging of serotonin 4 receptors in brain

AAS Tavares, F Caillé, O Barret, C Papin… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Serotonin 4 receptors (5-hydroxytryptamine receptor 4 [5HT4R]) hold promise as a novel
therapeutic approach to multiple brain disorders, including Alzheimer and Huntington …

Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate

N Saigal, R Pichika, B Easwaramoorthy… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Serotonin 5-HT1A receptors have been implicated in disorders of the central nervous system
and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability of …