Fatty acids are a common constituent of atherosclerotic plaque and may be synthesized in
the plaque itself. Fatty acid synthesis requires acetyl-coenzyme-A (CoA) as a main substrate …

Although it is accepted that the metabolic fate of 1-11C-acetate is different in tumors than in
myocardial tissue because of different clearance patterns, the exact pathway has not been …

To assess the uptake mechanism of a new branched fatty acid analogue, I-123 labeled 15-
iodophenyl-3-methyl pentadecanoic acid (BMIPP), BMIPP imaging was performed in …

Background Metabolic divergence of macrophages polarized into different phenotypes
represents a mechanistically relevant target for non-invasive characterization of …

Glucose metabolic activity expressed as 18F-FDG uptake may be increased in active
atherosclerotic plaque. Calcium depositions are often increased in mature atherosclerotic …

Several studies have highlighted the role of vascular 18F-NaF uptake as a marker of
ongoing calcium deposition. However, accumulation of 18F-NaF is often inconsistent with …

Tumors are often characterized by high levels of de novo fatty acid synthesis. The kinetics of
acetate incorporation into tricarboxylic acid cycle intermediates and into lipids suggest that …

Purpose Inflamed atherosclerotic plaques may rupture and cause acute myocardial
infarction, stroke and other thrombotic events. Early detection of these unstable plaques …

Background A radioactively labeled beta-methyl branched fatty acid analog, 123 I-15-(p-
iodophenyl)-3-methyl pentadecanoic acid (BMIPP), has been developed to probe regional …

This study describes the radiosynthesis and preliminary biologic evaluation of trans-9 (RS)-
18F-fluoro-3, 4 (RS, RS)-methyleneheptadecanoic acid (18F-FCPHA) as a new potential …