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PET measurement of the in vivo affinity of 11C-(R)-rolipram and the density of its target, phosphodiesterase-4, in the brains of conscious and anesthetized rats

T Itoh, K Abe, SS Zoghbi, O Inoue, J Hong… - Journal of Nuclear …, 2009 - Soc Nuclear Med
A variety of phosphodiesterases hydrolyze and terminate the effects of the intracellular
second messenger 3′, 5′-cyclic adenosine monophosphate (cAMP). Phosphodiesterase …
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Characterization of R-[11C] rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats

CM Lourenco, S Houle, AA Wilson… - Nuclear medicine and …, 2001 - Elsevier
The high-affinity phosphodiesterase-4 (PDE4) inhibitor R-rolipram and the less potent S-
enantiomer, both labeled with 11C, were evaluated in vivo in rats. Regional brain uptake of …
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PET of (R)-11C-rolipram binding to phosphodiesterase-4 is reproducible and sensitive to increased norepinephrine in the rat heart

AJ Thomas, JN DaSilva, M Lortie… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Phosphodiesterase-4 (PDE4) plays a critical role in the regulation of β-adrenergic receptor–
stimulated cyclic adenosine monophosphate cell signaling in the heart.(R)-rolipram, a PDE4 …
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Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)-and (S)-[11C] rolipram and their labeled …

M Kenk, M Greene, M Lortie, RA Dekemp… - Nuclear medicine and …, 2008 - Elsevier
INTRODUCTION: To complement recent studies using the high-affinity 11C-labeled
phosphodiesterase-4 (PDE4) inhibitor (R)-rolipram and the less active enantiomer (S)-[11C] …
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Imaging of cAMP‐specific phosphodiesterase‐IV: Comparison of [11C]Rolipram and [11C]Ro 20–1724 in rats

CM Lourenco, JN DaSilva, JJ Warsh, AA Wilson… - Synapse, 1999 - Wiley Online Library
The phosphodiesterase type IV (PDEIV) family of enzymes contributes to the metabolism of
cAMP formed by the stimulation of β‐adrenergic, A2‐adenosine, and H2‐histamine …
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First-in-human evaluation of 18F-PF-06445974, a PET radioligand that preferentially labels phosphodiesterase-4B

Y Wakabayashi, P Stenkrona, R Arakawa… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Phosphodiesterase-4 (PDE4), which metabolizes the second messenger cyclic adenosine
monophosphate (cAMP), has 4 isozymes: PDE4A, PDE4B, PDE4C, and PDE4D. PDE4B …
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Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image …

P Zanotti-Fregonara, SS Zoghbi, JS Liow, E Luong… - Neuroimage, 2011 - Elsevier
[11C](R)-rolipram provides a measure of the density of phosphodiesterase 4 (PDE4) in
brain, an enzyme that metabolizes cAMP. The aims of this study were to perform kinetic …
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Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A

A Harada, K Suzuki, S Miura, T Hasui… - Nuclear Medicine and …, 2015 - Elsevier
Abstract Introduction Phosphodiesterase 10A (PDE10A) is a dual-substrate PDE that
hydrolyzes both cAMP and cGMP and is selectively expressed in striatal medium spiny …
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Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [11C](R)-rolipram: comparison of two …

DR Sprague, M Fujita, YH Ryu, JS Liow… - Nuclear medicine and …, 2008 - Elsevier
INTRODUCTION:[11C](R)-Rolipram is a selective radioligand for positron emission
tomography (PET) imaging of phosphodiesterase 4, an enzyme that metabolizes 3′, 5 …
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[HTML][HTML] Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

KC Yang, V Stepanov, N Amini, S Martinsson… - European Journal of …, 2017 - Springer
Abstract Purpose [11 C] Lu AE92686 is a positron emission tomography (PET) radioligand
that has recently been validated for examining phosphodiesterase 10A (PDE10A) in the …
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