Knowledge about spatial and temporal patterns of β-amyloid (Aβ) accumulation is essential
for understanding Alzheimer disease (AD) and for design of antiamyloid drug trials. Here, we …

The accurate measurement of β-amyloid (Aβ) change using amyloid PET imaging is
important for Alzheimer disease research and clinical trials but poses several unique …

In this article, we describe an image analysis strategy with improved power for tracking
longitudinal amyloid-β (Aβ) PET changes and evaluating Aβ-modifying treatments. Methods …

Accurate measurement of changes in amyloid-β (Aβ) deposition over time is important in
longitudinal studies, particularly in anti-Aβ therapeutic trials. To achieve this, the optimal …

Purpose Complementing clinical findings with those generated by biomarkers—such as β-
amyloid-targeted positron emission tomography (PET) imaging—has been proposed as a …

Introduction This study examined a longitudinal trajectory of β-amyloid (Aβ) accumulation at
the predementia stage of Alzheimer's disease in the context of clinical trials. Methods …

Purpose In the initial evaluation of patients with suspected dementia and Alzheimer's
disease, there is no consensus on how to perform semiquantification of amyloid in such a …

Amyloid-β (Aβ) accumulation in Alzheimer disease (AD) is typically measured using SUV
ratio and the centiloid (CL) scale. The low spatial resolution of PET images is known to …

It was hypothesized that the brain β-amyloid buildup curve plateaus at an early symptomatic
stage of Alzheimer disease (AD). Atrophy-related partial-volume effects (PVEs) degrade …

Deposition of amyloid plaques is believed to be a central event in the development of
Alzheimer's disease (AD). The present study was undertaken to evaluate statistical methods …