599 Objectives: To investigate the multimodal neuroimaging relationship between Tau,
structural and functional brain parameters in healthy elders (HEs) and patients with …

Objective: To investigate the characteristics of tau deposition and its impact on functional
connectivity (FC) in Alzheimer's disease (AD). Methods: The hybrid PET/MRI scans with …

Purpose: 18F-Florzolotau is a novel second-generation tau radiotracer that shows higher
binding affinity and selectivity and no off-target binding. The proportion loss of functional …

Background The objectives of this study were to compare overall tau topography, inter-
regional connectivity of tau deposition between early-onset Alzheimer's disease (EOAD) and …

Background The association between tau pathology and neurodegeneration (atrophy) in
Alzheimer's disease (AD) is not fully understood. This study aimed to investigate whether tau …

Background The neuropathologic process of Alzheimer's disease (AD) is thought to affect
brain functionality even decades before any cognitive manifestations appear. Molecular …

Purpose The objective of this study is to investigate the hippocampal neurodegeneration
and its associated aberrant functions in mild cognitive impairment (MCI) and Alzheimer's …

Purpose Using PET imaging in a group of patients with Alzheimer's disease (AD), we
investigated whether level of education, a proxy for resilience, mitigates the harmful impact …

Background Neuroimaging modalities can measure different aspects of the disease process
in Alzheimer's disease (AD), such as atrophy on MRI, as well as hypometabolism and the …

Background We aimed to investigate the clinical correlates of principal components (PCs) of
tau positron emission tomography (PET) and their predictability for longitudinal changes in …