Assessment of efficacy of [11C]-MeAIB PET/CT as a biomarker of the system A amino acid transport: Comparison with [18F]-FDG and MRI in the patients with prostate …

T Higashi, R Nishii, S Kagawa, M Takahashi, Y Kishibe… - 2012 - Soc Nuclear Med
1418 Objectives Although [18F] FDG PET is established as one of the first choice imaging
modalities in the diagnosis of malignancies, there are several problems to solve in clinical …

11C-methylaminoisobutyric acid (MeAIB) PET for evaluation of prostate cancer: compared with 18F-fluorodeoxyglucose PET

MK Arimoto, T Higashi, R Nishii, S Kagawa… - Annals of nuclear …, 2016 - Springer
Abstract Objective α-N-methyl-11 C-methylaminoisobutyric acid (11 C-MeAIB) is a selective
substrate of system A amino acid transport, and known to accumulate in malignant lesions …

(18) F-FBPA as a tumor specific tracer of L-type amino acid transporter 1 (LAT1): PET evaluation in tumor and inflammation compared to (18) F-FDG and (11) C …

T Watabe, J Hatazawa - Hellenic Journal of Nuclear Medicine, 2015 - europepmc.org
Objective (18) F-FDG-PET is used worldwide for oncology patients. However, we sometimes
encounter false positive cases of (18) F-FDG PET, such as moderate uptake in the …

Increased expression of Ki-67 correlates with synthetic amino acid PET radiotracer uptake in prostate cancer

P Taleghani, R Amzat, A Osunkoya, B Savir-Baruch… - 2012 - Soc Nuclear Med
1097 Objectives anti-1-amino-3-[18 F] fluorocyclobutane-1-carboxylic acid (anti-3-[18 F]
FACBC) is a synthetic amino acid positron emission tomography (PET) radiotracer which is …

Comparison of system A and system L amino acid transports in human pancreas with C-11 MeAIB and C-11 MET PET study

R Nishii, S Kagawa, T Higashi, Y Kishibe, J Iwasaki… - 2009 - Soc Nuclear Med
1727 Objectives To clarify the difference between system A and L amino acid transport
imaging in clinical PET, we analyze the pharmacokinetics and the parametric images of [N …

Usefulness of system A amino acid transport PET imaging with C-11-MeAIB in diagnosing brain tumors: A comparison study with C-11-Methionine PET imaging

R Nishii, T Higashi, S Kagawa, Y Kishibe, M Takahashi… - 2012 - Soc Nuclear Med
1992 Objectives We have presented system A amino acid PET imaging with [N-methyl-C-11]
α-methylaminoisobutyric acid (MeAIB) in patients with glioblastoma multiforme (GBM) as a …

Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer

H Okudaira, N Shikano, R Nishii, T Miyagi… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid (anti–18F-FACBC) is an amino acid
PET tracer that has shown promise for visualizing prostate cancer. Therefore, we aimed to …

Initial imaging findings using [18f]GE-148 ([18F]FACBC) PET/CT in subjects with primary prostate cancer.

S Johansson, J Sorensen, MA Lax… - Journal of Clinical …, 2010 - ascopubs.org
e15138 Background: Existing imaging techniques have limitations for the detection and
staging of prostate cancer. 1-amino-3-[18F] fluorocyclobutane-1-carboxylic acid ([18F] GE …

Relationship between [14C] MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells …

S Kagawa, R Nishii, T Higashi, H Yamauchi… - Nuclear Medicine and …, 2017 - Elsevier
Introduction To clarify the difference between system A and L amino acid transport imaging
in PET clinical imaging, we focused on the use of α-[N-methyl-11 C]-methylaminoisobutyric …

18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET

T Watabe, H Ikeda, S Nagamori… - European journal of …, 2017 - Springer
Purpose The purpose of this study was to evaluate the usefulness of L-4-borono-2-18 F-
fluoro-phenylalanine (18 F-FBPA) as a tumor-specific probe, in comparison to 18 F-FDG and …