Preparation, biological evaluation, and pharmacokinetics of the human anti-HER1 monoclonal antibody panitumumab labeled with 86Y for quantitative PET of …
TK Nayak, K Garmestani, KE Baidoo… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Panitumumab, a human monoclonal antibody that binds to the epidermal growth factor
receptor (HER1), was approved by the Food and Drug Administration in 2006 for the …
receptor (HER1), was approved by the Food and Drug Administration in 2006 for the …
Zirconium-89 labeled panitumumab: a potential immuno-PET probe for HER1-expressing carcinomas
S Bhattacharyya, K Kurdziel, L Wei, L Riffle… - Nuclear medicine and …, 2013 - Elsevier
INTRODUCTION: Anti-HER1 monoclonal antibody (mAb), panitumumab (Vectibix) is a fully
human mAb approved by the FDA for the treatment of epidermal growth factor receptor …
human mAb approved by the FDA for the treatment of epidermal growth factor receptor …
PET imaging of HER1-expressing xenografts in mice with 86Y-CHX-A″-DTPA-cetuximab
TK Nayak, CAS Regino, KJ Wong, DE Milenic… - European journal of …, 2010 - Springer
Purpose Cetuximab is a recombinant, human/mouse chimeric IgG 1 monoclonal antibody
that binds to the epidermal growth factor receptor (EGFR/HER1). Cetuximab is approved for …
that binds to the epidermal growth factor receptor (EGFR/HER1). Cetuximab is approved for …
Immuno-PET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors
CW Menke-Van Der Houven, A McGeoch… - Journal of Nuclear …, 2019 - Soc Nuclear Med
PET imaging with radiolabeled drugs provides information on tumor uptake and dose-
dependent target interaction to support selection of an optimal dose for future efficacy …
dependent target interaction to support selection of an optimal dose for future efficacy …
[HTML][HTML] In vitro and in vivo pre-clinical analysis of a F(ab')2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers
KJ Wong, KE Baidoo, TK Nayak, K Garmestani… - EJNMMI research, 2011 - Springer
Background The objective of this study was to characterize the in vitro and in vivo properties
of the F (ab') 2 fragment of panitumumab and to investigate its potential for imaging and …
of the F (ab') 2 fragment of panitumumab and to investigate its potential for imaging and …
PET and MRI of metastatic peritoneal and pulmonary colorectal cancer in mice with human epidermal growth factor receptor 1–targeted 89Zr-labeled Panitumumab
TK Nayak, K Garmestani, DE Milenic… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Human epidermal growth factor receptor 1 (HER1) plays an important role in the
pathogenesis of colorectal cancer. Panitumumab is an anti-HER1 monoclonal antibody …
pathogenesis of colorectal cancer. Panitumumab is an anti-HER1 monoclonal antibody …
Receptor PET/CT and SPECT using an Affibody molecule for targeting and molecular imaging of HER2 positive cancer in animal xenografts and human breast cancer …
308 Objectives: Affibody® molecules, small non-immunoglobulin affinity ligands, can be
selected to virtually any target protein from combinatorial libraries based on a 58 amino acid …
selected to virtually any target protein from combinatorial libraries based on a 58 amino acid …
On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of a 124I-labeled affibody molecule and trastuzumab in a murine xenograft …
A Orlova, H Wållberg, S Stone-Elander… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Human epidermal growth factor receptor type 2 (HER2) is a tyrosine kinase, which is often
overexpressed in many carcinomas. Imaging HER2 expression in malignant tumors can …
overexpressed in many carcinomas. Imaging HER2 expression in malignant tumors can …
[HTML][HTML] HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers
Simple Summary HER3 is a known driver for oncogenesis and therapy resistance in solid
cancers. PET imaging could be a useful tool to non-invasively detect and monitor HER3 …
cancers. PET imaging could be a useful tool to non-invasively detect and monitor HER3 …
[HTML][HTML] Development and characterization of 89Zr-labeled panitumumab for immuno–positron emission tomographic imaging of the epidermal growth factor receptor
AJ Chang, RA De Silva, SE Lapi - Molecular imaging, 2013 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is overexpressed in the majority of
malignancies and has been associated with poor outcomes. Panitumumab, an anti-EGFR …
malignancies and has been associated with poor outcomes. Panitumumab, an anti-EGFR …