Does imaging αvβ3 integrin expression with PET detect changes in angiogenesis during bevacizumab therapy?
SN Rylova, E Barnucz, M Fani, F Braun… - Journal of Nuclear …, 2014 - Soc Nuclear Med
In recent years, there has been a growing interest in molecular imaging markers of tumor-
induced angiogenesis. Several radiolabeled RGD (arginine, glycine, aspartate) peptides …
induced angiogenesis. Several radiolabeled RGD (arginine, glycine, aspartate) peptides …
Quantitative PET imaging of tumor integrin αvβ3 expression with 18F-FRGD2
The development of noninvasive methods to visualize and quantify integrin αvβ3 expression
in vivo appears to be crucial for the success of antiangiogenic therapy based on integrin …
in vivo appears to be crucial for the success of antiangiogenic therapy based on integrin …
Radiolabeled RGD Tracer Kinetics Annotates Differential αvβ3 Integrin Expression Linked to Cell Intrinsic and Vessel Expression
Purpose The purpose of this paper is to study the association between RGD binding kinetics
and α v β 3 integrin receptor density in the complex tumor milieu. Procedures We assessed …
and α v β 3 integrin receptor density in the complex tumor milieu. Procedures We assessed …
Use of a novel Arg-Gly-Asp radioligand, 18F-AH111585, to determine changes in tumor vascularity after antitumor therapy
MS Morrison, SA Ricketts, J Barnett… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Despite the recent development of various radiolabeled Arg-Gly-Asp (RGD) peptides for
imaging the αvβ3 integrin receptor, relatively little attention has been focused on the ability …
imaging the αvβ3 integrin receptor, relatively little attention has been focused on the ability …
PET-based human dosimetry of the dimeric αvβ3 integrin ligand 68Ga-DOTA-E-[c (RGDfK)] 2, a potential tracer for imaging tumor angiogenesis
V López-Rodríguez, C Galindo-Sarco… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Peptides containing the Arg-Gly-Asp (RGD) sequence have high affinity for αvβ3 integrin
receptors overexpressed in tumor cells. The objective of this research was to determine the …
receptors overexpressed in tumor cells. The objective of this research was to determine the …
In vivo characterization of 4 68Ga-labeled multimeric RGD peptides to image αvβ3 integrin expression in 2 human tumor xenograft mouse models
D Lobeek, GM Franssen, MT Ma… - Journal of Nuclear …, 2018 - Soc Nuclear Med
αvβ3 integrins play an important role in angiogenesis and cell migration in cancer and are
highly expressed on the activated endothelial cells of newly formed blood vessels. Here, we …
highly expressed on the activated endothelial cells of newly formed blood vessels. Here, we …
Imaging integrin αvβ3 on blood vessels with 111In-RGD2 in head and neck tumor xenografts
SYA Terry, K Abiraj, C Frielink… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Arginine-glycine-aspartic acid (RGD)–based imaging tracers allow specific imaging of
integrin αvβ3, a protein overexpressed during angiogenesis, leading to the possibility that it …
integrin αvβ3, a protein overexpressed during angiogenesis, leading to the possibility that it …
Reproducibility study of [18F]FPP(RGD)2 uptake in murine models of human tumor xenografts
E Chang, S Liu, G Gowrishankar, S Yaghoubi… - European Journal of …, 2011 - Springer
Abstract Purpose An 18 F-labeled PEGylated arginine-glycine-aspartic acid (RGD) dimer
{[18 F] FPP (RGD) 2} has been used to image tumor α v β 3 integrin levels in preclinical and …
{[18 F] FPP (RGD) 2} has been used to image tumor α v β 3 integrin levels in preclinical and …
Complementary, selective PET imaging of integrin subtypes α5β1 and αvβ3 using 68Ga-aquibeprin and 68Ga-avebetrin
Despite in vivo mapping of integrin αvβ3 expression being thoroughly investigated in recent
years, its clinical value is still not well defined. For imaging of angiogenesis, the integrin …
years, its clinical value is still not well defined. For imaging of angiogenesis, the integrin …
PET of αvβ3-integrin and αvβ5-integrin expression with 18F-fluciclatide for assessment of response to targeted therapy: ready for prime time?
AJ Beer, M Schwaiger - Journal of Nuclear Medicine, 2011 - Soc Nuclear Med
Angiogenesis, the formation of new blood vessels, is one of the hallmarks of cancer and a
key process in the growth of solid tumors (1). Therefore, this process could be targeted for …
key process in the growth of solid tumors (1). Therefore, this process could be targeted for …