In vivo measurement of D2 receptor density and affinity for 18F-(3-N-methyl) benperidol in the rat striatum with a PET system for small laboratory animals
S Nikolaus, R Larisch, M Beu… - Journal of Nuclear …, 2003 - Soc Nuclear Med
A recent investigation showed that intracerebral radioactivity concentrations can reliably be
quantified in vivo with a small-animal PET device. The purpose of the current study was to …
quantified in vivo with a small-animal PET device. The purpose of the current study was to …
Specific, reversible binding of [18F] benperidol to baboon D2 receptors: PET evaluation of an improved 18F-labeled ligand
SM Moerlein, JS Perlmutter, MJ Welch - Nuclear medicine and biology, 1995 - Elsevier
[18F] Benperidol ([18F] BP), a positron-emitting analogue of the dopaminergic D2 antagonist
benperidol, was evaluated as a radiopharmaceutical for use with positron emission …
benperidol, was evaluated as a radiopharmaceutical for use with positron emission …
Radiation dosimetry of [18F](N-methyl) benperidol as determined by whole-body PET imaging of primates
SM Moerlein, JS Perlmutter, PD Cutler… - Nuclear medicine and …, 1997 - Elsevier
Radiation absorbed doses due to IV administration of [18F](N-methyl) benperidol ([18F]
NMB) were estimated by whole-body PET imaging of nonhuman primates. Time-activity …
NMB) were estimated by whole-body PET imaging of nonhuman primates. Time-activity …
In Vivo Kinetics of [18F](N-Methyl)Benperidol: A Novel PET Tracer for Assessment of Dopaminergic D2-Like Receptor Binding
SM Moerlein, JS Perlmutter… - Journal of Cerebral …, 1997 - journals.sagepub.com
A novel D2-like receptor-binding radioligand,[18F](N-methyl) benperidol ([18F] NMB), was
evaluated via positron emission tomographic (PET) imaging studies of baboons.[18F] NMB …
evaluated via positron emission tomographic (PET) imaging studies of baboons.[18F] NMB …
Specific binding of 3N-(2′-[18F] fluoroethyl) benperidol to primate cerebral dopaminergic D2 receptors demonstrated in vivo by PET
SM Moerlein, JS Perlmutter - Neuroscience letters, 1992 - Elsevier
Abstract 3N-(2′-[18 F] Fluoroethyl) benperidol ([18 F] FEB) an 18 F-labeled analogue of the
D 2 antagonist benperidol, was evaluated as a tracer for positron emission tomography …
D 2 antagonist benperidol, was evaluated as a tracer for positron emission tomography …
Production of fluorine-18 labeled (3-N-methyl) benperidol for PET investigation of cerebral dopaminergic receptor binding
SM Moerlein, WR Banks, D Parkinson - International journal of radiation …, 1992 - Elsevier
The multi-millicurie synthesis of the D-2 receptor ligand [18 F](3-N-methyl) benperidol (NMB;
1-[3-(4′-[18 F] fluorobenzoyl) propyl]-4-(2-keto-3-methyl-1-benzimidazolinyl) piperidine) is …
1-[3-(4′-[18 F] fluorobenzoyl) propyl]-4-(2-keto-3-methyl-1-benzimidazolinyl) piperidine) is …
Imaging of striatal dopamine D2 receptors with a PET system for small laboratory animals in comparison with storage phosphor autoradiography: a validation study …
S Nikolaus, R Larisch, M Beu, H Vosberg… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Several groups have developed high-resolution PET systems and shown the feasibility of in
vivo studies on small laboratory animals. In this investigation, one of these systems was …
vivo studies on small laboratory animals. In this investigation, one of these systems was …
Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates
JAV Antenor-Dorsey, R Laforest, SM Moerlein… - European journal of …, 2008 - Springer
Abstract Purpose N-([11 C] methyl) benperidol ([11 C] NMB) can be used for positron
emission tomography (PET) measurements of D 2-like dopamine receptor binding in vivo …
emission tomography (PET) measurements of D 2-like dopamine receptor binding in vivo …
Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl) benperidol in humans
JAV Antenor-Dorsey, J Markham, SM Moerlein… - Nuclear medicine and …, 2008 - Elsevier
Positron emission tomography measurements of dopaminergic D2-like receptors may
provide important insights into disorders such as Parkinson's disease, schizophrenia …
provide important insights into disorders such as Parkinson's disease, schizophrenia …
PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756
A Abi‐Dargham, N Simpson, L Kegeles, R Parsey… - Synapse, 1999 - Wiley Online Library
Abstract NNC 756 ((+)‐8‐chloro‐5‐(2, 3‐dihydrobenzofuran‐7‐yl)‐7‐hydroxy‐3‐methyl‐2,
3, 4, 5‐tetrahydro‐1H‐3‐benzazepine) is a new high affinity dopamine (DA) D1 receptor …
3, 4, 5‐tetrahydro‐1H‐3‐benzazepine) is a new high affinity dopamine (DA) D1 receptor …