How should lumped constant be estimated for hepatic 18F-FDG glucose in humans?

S Keiding - Journal of Nuclear Medicine, 2015 - Soc Nuclear Med
Hepatic glucose metabolism plays a key role in human metabolic homeostasis. In the
current issue of The Journal of Nuclear Medicine, Trägårdh et al.(1) examine the challenges …

Methodologic considerations for quantitative 18F-FDG PET/CT studies of hepatic glucose metabolism in healthy subjects

M Trägårdh, N Møller, M Sørensen - Journal of Nuclear Medicine, 2015 - Soc Nuclear Med
PET with the glucose analog 18F-FDG is used to measure regional tissue metabolism of
glucose. However, 18F-FDG may have affinities different from those of glucose for plasma …

Does 2-FDG PET accurately reflect quantitative in vivo glucose utilization?

JR Barrio, SC Huang, N Satyamurthy… - Journal of Nuclear …, 2020 - Soc Nuclear Med
2-Deoxy-2-18F-fluoro-d-glucose (2-FDG) with PET is undeniably useful in the clinic, being
able, among other uses, to monitor change over time using the 2-FDG SUV metric. This …

Is the effect of hyperglycemia on liver 18F-FDG standardized uptake value really clinically significant?

S Altmayer, M Zanon, C Sprinz, G Watte… - European Journal of …, 2019 - Springer
Dear Sir, We have read with interest the recent work by Eskian et al. entitled BEffect of blood
glucose level on SUV in 18F-FDG PET-scan: a systematic review and meta-analysis of …

Analysis of metabolism of 6FDG: a PET glucose transport tracer

RF Muzic Jr, V Chandramouli, HM Huang, C Wu… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: We are developing 18F-labeled 6-fluoro-6-deoxy-d-glucose ([18F] 6FDG)
as a tracer of glucose transport. As part of this process it is important to characterize and …

The FDG lumped constant in normal human brain

MM Graham, M Muzi, AM Spence… - Journal of Nuclear …, 2002 - Soc Nuclear Med
The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc)
from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 …

What is in a number? The FDG lumped constant in the rat brain

KA Krohn, M Muzi, AM Spence - Journal of Nuclear Medicine, 2007 - Soc Nuclear Med
PET with 18F-FDG is being used in humans to study regional brain metabolism in normal
and disease states. The underpinning of this approach is that FDG, like glucose, is …

Effects of varying serum glucose levels on 18F-FDG biodistribution

RL Webb, E Landau, D Klein, J DiPoce… - Nuclear medicine …, 2015 - journals.lww.com
Objective Hyperglycemia has been shown to influence fluorine-18 fluorodeoxyglucose (18 F-
FDG) uptake in tumor cells. Therefore, patients are instructed to fast for 6 h, while …

A method for generating image-derived input function in quantitative 18F-FDG PET study based on the monotonicity of the input and output function curve

S Zhou, K Chen, EM Reiman, D Li… - Nuclear medicine …, 2012 - journals.lww.com
Objective A method of defining the image-derived input function (IDIF) was introduced and
evaluated for the quantification of the regional cerebral metabolic rate of glucose in PET …

Reply: Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG

SL Thorn, R deKemp, T Dumouchel… - Journal of Nuclear …, 2014 - Soc Nuclear Med
TO THE EDITOR: I read with interest the recent publication by Thorn et al.(1) using vena
cava image-derived input functions for quantification of myocardial glucose uptake (MGU) …