Kinetic modeling of 3′-deoxy-3′-18F-fluorothymidine for quantitative cell proliferation imaging in subcutaneous tumor models in mice
SJ Kim, JS Lee, KC Im, SY Kim, SA Park… - Journal of Nuclear …, 2008 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) is a thymidine analog that was developed for
measuring tumor proliferation with PET. The aim of this study was to establish a kinetic …
measuring tumor proliferation with PET. The aim of this study was to establish a kinetic …
Dynamic small-animal PET imaging of tumor proliferation with 3′-deoxy-3′-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas
MS Bradbury, D Hambardzumyan… - Journal of Nuclear …, 2008 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT), a partially metabolized thymidine analog,
has been used in preclinical and clinical settings for the diagnostic evaluation and …
has been used in preclinical and clinical settings for the diagnostic evaluation and …
Kinetic analysis of 3′-deoxy-3′-fluorothymidine PET studies: validation studies in patients with lung cancer
M Muzi, H Vesselle, JR Grierson… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Assessing cellular proliferation provides a direct method to measure the in vivo growth of
cancer. We evaluated the application of a model of 3′-deoxy-3′-18F-fluorothymidine (18F …
cancer. We evaluated the application of a model of 3′-deoxy-3′-18F-fluorothymidine (18F …
18F-fluorothymidine kinetics of malignant brain tumors
C Schiepers, W Chen, M Dahlbom, T Cloughesy… - European journal of …, 2007 - Springer
Purpose 18 F-labeled deoxy-fluorothymidine (FLT), a marker of cellular proliferation, has
been used in PET tumor imaging. Here, the FLT kinetics of malignant brain tumors were …
been used in PET tumor imaging. Here, the FLT kinetics of malignant brain tumors were …
Impact of Anesthetics on 3′-[18F]Fluoro-3′-Deoxythymidine ([18F]FLT) Uptake in Animal Models of Cancer and Inflammation
K Fuchs, D Kukuk, M Mahling… - Molecular …, 2013 - journals.sagepub.com
The aim of this study was to evaluate the impact of different anesthetics on 3′-[18F] fluoro-
3′-deoxythymidine ([18F] FLT) uptake in carcinomas and arthritic ankles. To determine the …
3′-deoxythymidine ([18F] FLT) uptake in carcinomas and arthritic ankles. To determine the …
Evaluation of 3′-deoxy-3′-18F-fluorothymidine for monitoring tumor response to radiotherapy and photodynamic therapy in mice
M Sugiyama, H Sakahara, K Sato… - Journal of Nuclear …, 2004 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) has been suggested as a new PET tracer for
imaging tumor proliferation. We investigated the use of 18F-FLT to monitor the response of …
imaging tumor proliferation. We investigated the use of 18F-FLT to monitor the response of …
Single-cell characterization of 18F-FLT uptake with radioluminescence microscopy
D Sengupta, G Pratx - Journal of Nuclear Medicine, 2016 - Soc Nuclear Med
The radiotracer 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) is commonly used to measure
cell proliferation in vivo. As a marker of cell proliferation, 18F-FLT is expected to be …
cell proliferation in vivo. As a marker of cell proliferation, 18F-FLT is expected to be …
[HTML][HTML] Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging: Laboratory analysis of serial blood …
E Turcotte, LW Wiens, JR Grierson, LM Peterson… - BMC nuclear …, 2007 - Springer
Background 18 F-FLT is a novel PET radiotracer which has demonstrated a strong potential
utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory …
utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory …
Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferation
N Oyama, DE Ponde, C Dence, J Kim… - Journal of Nuclear …, 2004 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) has been recently described as a
radiopharmaceutical for measuring cellular proliferation using PET imaging. Evaluation of …
radiopharmaceutical for measuring cellular proliferation using PET imaging. Evaluation of …
[HTML][HTML] Noninvasive quantification of 18F-FLT human brain PET for the assessment of tumour proliferation in patients with high-grade glioma
H Backes, R Ullrich, B Neumaier, L Kracht… - European journal of …, 2009 - Springer
Purpose Compartmental modelling of 3′-deoxy-3′-[18 F]-fluorothymidine (18 F-FLT) PET-
derived kinetics provides a method for noninvasive assessment of the proliferation rate of …
derived kinetics provides a method for noninvasive assessment of the proliferation rate of …