The optimal imaging window for dysplastic colorectal polyp detection using c-Met–targeted fluorescence molecular endoscopy

SJ de Jongh, JPM Vrouwe, FJ Voskuil… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Fluorescence molecular endoscopy (FME) is an emerging technique that has the potential to
improve the 22% colorectal polyp detection miss-rate. We determined the optimal dose-to …

Molecular fluorescence endoscopy targeting vascular endothelial growth factor a for improved colorectal polyp detection

JJ Tjalma, PB Garcia-Allende, E Hartmans… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Small and flat adenomas are known to carry a high miss-rate during standard white-light
endoscopy. Increased detection rate may be achieved by molecular fluorescence …

[HTML][HTML] Potential red-flag identification of colorectal adenomas with wide-field fluorescence molecular endoscopy

E Hartmans, JJJ Tjalma, MD Linssen, PBG Allende… - Theranostics, 2018 - ncbi.nlm.nih.gov
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated
adenomas/polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch …

Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met

J Burggraaf, IMC Kamerling, PB Gordon, L Schrier… - Nature medicine, 2015 - nature.com
Colon cancer prevention currently relies on colonoscopy using white light to detect and
remove polyps, but small and flat polyps are difficult to detect and frequently missed when …

[HTML][HTML] Multi-spectral fluorescence imaging of colon dysplasia in vivo using a multi-spectral endoscopy system

SM Bae, DJ Bae, EJ Do, G Oh, SW Yoo, GJ Lee… - Translational …, 2019 - Elsevier
Abstract BACKGROUND AND STUDY AIM: To develop a molecular imaging endoscopic
system that eliminates tissue autofluorescence and distinguishes multiple fluorescent …

Colorectal polyps: Targets for fluorescence‐guided endoscopy to detect high‐grade dysplasia and T1 colorectal cancer

N Dekkers, E Zonoobi, H Dang… - United European …, 2023 - Wiley Online Library
Background Differentiating high‐grade dysplasia (HGD) and T1 colorectal cancer (T1CRC)
from low‐grade dysplasia (LGD) in colorectal polyps can be challenging. Incorrect …

[HTML][HTML] Highlighting the Undetectable—Fluorescence Molecular Imaging in Gastrointestinal Endoscopy

JA Stibbe, P Hoogland, FB Achterberg… - Molecular Imaging and …, 2023 - Springer
Flexible high-definition white-light endoscopy is the current gold standard in screening for
cancer and its precursor lesions in the gastrointestinal tract. However, miss rates are high …

[HTML][HTML] C-Met targeted fluorescence molecular endoscopy in Barrett's esophagus patients and identification of outcome parameters for phase-I studies

SJ de Jongh, FJ Voskuil, I Schmidt, A Karrenbeld… - Theranostics, 2020 - ncbi.nlm.nih.gov
Fluorescence molecular endoscopy (FME) is an emerging technique in the field of
gastroenterology that holds potential to improve diagnosis and guide therapy, by serving as …

An unmet medical need: advances in endoscopic imaging of colorectal neoplasia

A Stallmach, C Schmidt, A Watson… - Journal of …, 2011 - Wiley Online Library
Gastrointestinal cancer is a major public health problem worldwide. Detection of early
neoplastic lesions in gastrointestinal tract is essential for cure, because prognosis and …

[HTML][HTML] Imaging in colorectal cancer: progress and challenges for the clinicians

E Van Cutsem, HMW Verheul, P Flamen, P Rougier… - Cancers, 2016 - mdpi.com
The use of imaging in colorectal cancer (CRC) has significantly evolved over the last twenty
years, establishing important roles in surveillance, diagnosis, staging, treatment selection …