DISCUSSION Although poorly understood in the past, much has been learned about the
metabolism of gallium and similar ions in recent years (5— 12). Studieshave shown that …

LETTERSTO THE EDITOR diation) causeincreasedurinary excretionof gallium
anddecreased tumor uptake (5). Any decreasein the number of available serum iron-binding …

As a crucial step toward the understanding of the tumor localization of gallium, we have re-
investigated its binding and transport in blood. The studies were performed in vivo by …

(1). Subsequently, 67Gahas been shown to localize in a variety of tumors (2, 3). In nuclear
medicine, the utility of 67Ga as a tumor-imaging agent is variable. Many types of tumors …

Min-Fu Tsan and Ursula Scheffel shown that 67Gain normal plasma isalmost exclusively
bound to transferrin. Like Fe3@, 67Ga binds to the two specific metal binding sites of human …

DISCUSSION To correlate the role of TF in 67Galocalization with scintigrams and actual
tissue concentration, it is necessary to determine the percentage ofthe main nonprotein …

LETTER TO THE EDITOR: We would like to comment on the recent article of Anghileri et
al.(/), which appeared in the May, 1988 issue of the Journal. We believe that none of the …

After iv administration, gallium-67 citrate is taken up by liver cells. Subcellular Ga-67 is
associated with lysosomes and probably also with a microsomal fraction within the cell (1 …

We have observeda galliumscan in a 78-yr-oldmale that showed intense uptake bilaterally
in breast tissue, with in creased uptake in the left hilar region and possibly very mildly …

DTPA,histamine,humanalbumin,transferrin,*and Page 1 In 1969, Edwards and Hayes (1) noted
that gal lium-67 accumulated in involved lymph nodes in Hodgkin's disease. Since then, Ga-67 …