Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease
(AD) brain tissue. It is therefore of great interest to develop a PET tracer for visualizing …

The PET tracer 11C-deuterium-L-deprenyl (11C-DED) has been used to visualize activated
astrocytes in vivo in patients with Alzheimer disease (AD). In this multitracer PET study, early …

Accurate, early differentiation of dementias will become increasingly important as new
therapies are introduced. Differential diagnosis by standard clinical criteria has limited …

A neuroinflammatory reaction in Alzheimer disease (AD) brains involves reactive astrocytes
that overexpress monoamine oxidase-B (MAO-B). 18F-(S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2 …

Reactive gliosis, characterized by reactive astrocytes and activated microglia, contributes
greatly to neurodegeneration throughout the course of Alzheimer disease (AD). Reactive …

Abstract 11C-BU99008 is a novel positron emission tomography (PET) tracer that enables
selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated …

PET studies with biomarkers of regional neuronal activity (cerebral glucose metabolism or
blood flow [CBF]) and amyloid-β (Aβ) depositions provide complementary information for the …

The purpose of this study was to compare the diagnostic accuracy of glucose metabolism
and amyloid deposition as demonstrated by 18F-FDG and Pittsburg Compound B (PiB) PET …

Studying autosomal dominant Alzheimer's disease (ADAD), caused by gene mutations
yielding nearly complete penetrance and a distinct age of symptom onset, allows …

11C-Pittsburgh Compound-B (11C-PIB) and 18F-(2-(1-{6-[(2-[18F] fluoroethyl)(methyl)
amino]-2-naphthyl} ethylidene)(18F-FDDNP) have been developed as PET tracers for in …