Department ofRadiology, University ofPennsylvania, Philadelphia, Pennsylvania
management. It is possible to achieve this by using 1231.. labeled compounds in two …

Several groups have developed high-resolution PET systems and shown the feasibility of in
vivo studies on small laboratory animals. In this investigation, one of these systems was …

Methods: Multilinear regression analysis (MLRA) and graphical analysis (GA) using plasma
parent (P) plus metabolite (M) activities as input and time activities of receptor-free (RF …

Subjectschosen for initial studies were male volunteers (a total of nine, age: 18— 50,
mean= 28) who had no history of prior neurologic or psychiatric disorders. Informed consent …

ÖPECT imaging of dopamine D2-receptors using I23l-labeled benzamide analogs such as
[I23l] iodobenzamide (IBZM) and [I23l] iodobenzofuran (IBF) is a potentially useful tool to …

FIGURE 3. Percent specific striatimi uptake for 123l-epidepridecompared with 123I-IBZM
(mean ±sd).* p< 0.05 compared with 123I-IBZM,** p< 0.01 compared with 123I-IBZM. the …

Dynamic SPECT was performed in two healthy male volunteers with a single slice brain
dedicated camera (Strichman Medical Equipment 810, first study) and a rotating gamma …

The regional brain distribution and pharmacological specificity of three high affinity tracers
for the dopamine (DA) D 2 receptor:[123 I] IBF,[123 I] epidepride, and [123 I] 2′-ISP were …

The sequenceof measurementswas designedto acquirethe early emission images
immediately after the transmission scans without moving the subject so that the two sets of …

PD, the previouslyobserved inverse correlationbetween levodopadosageand D2-
receptordensityappearsto be most prominentin the leastdopamine-deplatedregion …