The clinical application of fluorescence-guided surgery in head and neck cancer
S van Keulen, N Nishio, S Fakurnejad… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Although surgical resection has been the primary treatment modality of solid tumors for
decades, surgeons still rely on visual cues and palpation to delineate healthy from …
decades, surgeons still rely on visual cues and palpation to delineate healthy from …
Characterizing the utility and limitations of repurposing an open-field optical imaging device for fluorescence-guided surgery in head and neck cancer patients
LS Moore, EL Rosenthal, TK Chung… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The purpose of this study was to assess the potential of US Food and Drug Administration–
cleared devices designed for indocyanine green–based perfusion imaging to identify cancer …
cleared devices designed for indocyanine green–based perfusion imaging to identify cancer …
Fluorescent molecular imaging can improve intraoperative sentinel margin detection in oral squamous cell carcinoma
G Krishnan, NS van den Berg, N Nishio… - Journal of Nuclear …, 2022 - Soc Nuclear Med
In head and neck cancer, a major limitation of current intraoperative margin analysis is the
ability to detect areas most likely to be positive based on specimen palpation, especially for …
ability to detect areas most likely to be positive based on specimen palpation, especially for …
Intraoperative tumor assessment using real-time molecular imaging in head and neck cancer patients
S van Keulen, N Nishio, S Fakurnejad… - Journal of the …, 2019 - journals.lww.com
BACKGROUND: In head and neck cancer, surgical resection using primarily visual and
tactile feedback is considered the gold standard for solid tumors. Due to high numbers of …
tactile feedback is considered the gold standard for solid tumors. Due to high numbers of …
Optimal dosing strategy for fluorescence-guided surgery with panitumumab-IRDye800CW in head and neck cancer
N Nishio, NS van den Berg, S van Keulen… - Molecular imaging and …, 2020 - Springer
Purpose To identify the optimal dosing strategy for fluorescence-guided surgery in patients
with head and neck squamous cell carcinoma, we conducted a dose-ranging study …
with head and neck squamous cell carcinoma, we conducted a dose-ranging study …
Intraoperative fluorescence‐guided surgery in head and neck squamous cell carcinoma
YJ Lee, G Krishnan, N Nishio… - The …, 2021 - Wiley Online Library
The rate of positive margins in head and neck cancers has remained stagnant over the past
three decades and is consistently associated with poor overall survival. This suggests that …
three decades and is consistently associated with poor overall survival. This suggests that …
Specimen mapping in head and neck cancer using fluorescence imaging
N Teraphongphom, CS Kong… - Laryngoscope …, 2017 - Wiley Online Library
Overview Although the agreed‐upon standard is circumferential pathology analysis of the
interface between the resected specimen and the patient, there is currently no consensus on …
interface between the resected specimen and the patient, there is currently no consensus on …
Determination of tumor margins with surgical specimen mapping using near-infrared fluorescence
For many solid tumors, surgical resection remains the gold standard and tumor-involved
margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence …
margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence …
Fluorescence imaging to localize head and neck squamous cell carcinoma for enhanced pathological assessment
JM Warram, E de Boer, GM van Dam… - The Journal of …, 2016 - Wiley Online Library
Accurately identifying close or positive margins in real‐time permits re‐excision during
surgical procedures. Intraoperative assessment of margins via gross examination and frozen …
surgical procedures. Intraoperative assessment of margins via gross examination and frozen …
Real-time fluorescence imaging in intraoperative decision making for cancer surgery
LJ Lauwerends, PBAA van Driel, RJB de Jong… - The Lancet …, 2021 - thelancet.com
Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …
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