Although surgical resection has been the primary treatment modality of solid tumors for
decades, surgeons still rely on visual cues and palpation to delineate healthy from …

The purpose of this study was to assess the potential of US Food and Drug Administration–
cleared devices designed for indocyanine green–based perfusion imaging to identify cancer …

In head and neck cancer, a major limitation of current intraoperative margin analysis is the
ability to detect areas most likely to be positive based on specimen palpation, especially for …

BACKGROUND: In head and neck cancer, surgical resection using primarily visual and
tactile feedback is considered the gold standard for solid tumors. Due to high numbers of …

Purpose To identify the optimal dosing strategy for fluorescence-guided surgery in patients
with head and neck squamous cell carcinoma, we conducted a dose-ranging study …

The rate of positive margins in head and neck cancers has remained stagnant over the past
three decades and is consistently associated with poor overall survival. This suggests that …

Overview Although the agreed‐upon standard is circumferential pathology analysis of the
interface between the resected specimen and the patient, there is currently no consensus on …

For many solid tumors, surgical resection remains the gold standard and tumor-involved
margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence …

Accurately identifying close or positive margins in real‐time permits re‐excision during
surgical procedures. Intraoperative assessment of margins via gross examination and frozen …

Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …