The κ-opioid receptor (KOR) has been implicated in depression, addictions, and other
central nervous system disorders and, thus, is an important target for drug development. We …

The κ-opioid receptors (KORs) are implicated in several neuropsychiatric diseases and
addictive disorders. PET with radioligands provides a means to image the KOR in vivo and …

Kappa-opioid receptors (KOR) are believed to be involved in the pathophysiology of
depression, anxiety disorders, drug abuse, and alcoholism. To date, only 1 tracer, the KOR …

Studies have shown κ-opioid receptor (KOR) abnormalities in addictive disorders, other
central nervous system diseases, and Alzheimer's disease. We have developed the first set …

The κ-opioid receptors (KOR) are involved in mood disorders and addictive conditions. In
vivo imaging studies of this receptor in humans have not been reported because of the lack …

The κ-opioid receptor (KOR) is implicated in various neuropsychiatric disorders. We
previously evaluated an agonist tracer, 11C-GR103545, for PET imaging of KOR in humans …

Brain κ-opioid receptors (ORs) may be involved in several pathologic conditions, such as
addiction, psychosis, and seizures.(±)-4-Methoxycarbonyl-2-[(1-pyrrolidinylmethyl]-1-[(3, 4 …

The kappa opioid receptor (KOR) is involved in depression, alcoholism, and drug abuse.
The current agonist radiotracer 11C-GR103545 is not ideal for imaging KOR due to its slow …

11C-LY2795050 is a novel κ-selective antagonist PET tracer. The in vitro binding affinities (K
i) of LY2795050 at the κ-opioid (KOR) and μ-opioid (MOR) receptors are 0.72 and 25.8 nM …

11C-LY2795050 is a new antagonist PET radioligand for the κ opioid receptor (KOR). In this
study, we assessed the reproducibility of the binding parameters of 11C-LY2795050 in …