In vitro and in vivo application of radiolabeled gastrin-releasing peptide receptor ligands in breast cancer

SU Dalm, JWM Martens, AM Sieuwerts… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Breast cancer (BC) consists of multiple subtypes defined by various molecular
characteristics, for instance, estrogen receptor (ER) expression. Methods for visualizing BC …

Expression of gastrin-releasing peptide receptor in breast cancer and its association with pathologic, biologic, and clinical parameters: a study of 1,432 primary tumors

C Morgat, G MacGrogan, V Brouste… - Journal of Nuclear …, 2017 - Soc Nuclear Med
A growing body of evidence suggests that gastrin-releasing peptide receptor (GRPR) might
be a valuable target in breast cancer. To understand which patients can be potential …

Gastrin-releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry

C Van de Wiele, P Phonteyne, P Pauwels… - Journal of Nuclear …, 2008 - Soc Nuclear Med
This study reports on the uptake of 99mTc-RP527 by human breast carcinoma and its
relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by …

[HTML][HTML] Gastrin-releasing peptide receptor imaging in breast cancer using the receptor antagonist 68Ga-RM2 and PET

C Stoykow, T Erbes, HR Maecke, S Bulla… - Theranostics, 2016 - ncbi.nlm.nih.gov
Introduction: The gastrin-releasing peptide receptor (GRPR) is overexpressed in breast
cancer. The present study evaluates GRPR imaging as a novel imaging modality in breast …

[HTML][HTML] Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors

A Accardo, F Galli, R Mansi, L Del Pozzo, M Aurilio… - EJNMMI research, 2016 - Springer
Background Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been
documented in several human neoplasms such as breast, prostate, and ovarian cancer …

Targeted imaging of gastrin-releasing peptide receptors with 99mTc-EDDA/HYNIC-[Lys3]-bombesin: biokinetics and dosimetry in women

CL Santos-Cuevas, G Ferro-Flores… - Nuclear medicine …, 2008 - journals.lww.com
Background The gastrin-releasing peptide receptor (GRP-R) is expressed in several normal
human tissues and is overexpressed in various human tumors including breast, prostate …

[HTML][HTML] Comparison of the binding of the gastrin-releasing peptide receptor (GRP-R) antagonist 68Ga-RM2 and 18F-FDG in breast cancer samples

C Morgat, R Schollhammer, G Macgrogan, N Barthe… - PloS one, 2019 - journals.plos.org
The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor
(ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of …

Clinical relevance of targeting the gastrin-releasing peptide receptor, somatostatin receptor 2, or chemokine CXC motif receptor 4 in breast cancer for imaging and …

SU Dalm, AM Sieuwerts, MP Look… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Imaging and therapy using radioligands targeting receptors overexpressed on tumor cells is
successfully applied in neuroendocrine tumor patients. Because expression of the gastrin …

Is there a role for agonist gastrin-releasing peptide receptor radioligands in tumour imaging?

C Van de Wiele, F Dumont, S Van Belle… - Nuclear medicine …, 2001 - journals.lww.com
Gastrin-releasing peptide (GRP) has been shown to be a tumour growth stimulating agent
for a number of normal and human cancer cell lines. The tumour growth effect is a direct …

177Lu-AMBA: synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer

LE Lantry, E Cappelletti, ME Maddalena… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Gastrin-releasing peptide receptors (GRP-R) are upregulated in many cancers, including
prostate, breast, and lung. We describe a new radiolabeled bombesin (BBN) analog for …