Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) in preclinical models of cancer
S Valtorta, S Belloli, F Sanvito, V Masiello… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Hypoxic regions are present in different types of cancer and are a negative prognostic factor
for disease progression and response to therapy. 18F-fluoroazomycin-arabinofuranoside …
for disease progression and response to therapy. 18F-fluoroazomycin-arabinofuranoside …
Copper-64-diacetyl-bis (N (4)-methylthiosemicarbazone) pharmacokinetics in FaDu xenograft tumors and correlation with microscopic markers of hypoxia
PURPOSE: The behavior of copper-64-diacetyl-bis (N (4)-methylthiosemicarbazone)(64Cu-
ATSM) in hypoxic tumors was examined through a combination of in vivo dynamic positron …
ATSM) in hypoxic tumors was examined through a combination of in vivo dynamic positron …
Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM
P Burgman, JA O'Donoghue, JS Lewis… - Nuclear medicine and …, 2005 - Elsevier
BACKGROUND: Cu-diacetyl-bis (N4-methylthiosemicarbazone)[Cu-ATSM] is a potential
marker for tumor hypoxia that has been under evaluation for clinical use. In this study, we …
marker for tumor hypoxia that has been under evaluation for clinical use. In this study, we …
Autoradiographic and small-animal PET comparisons between 18F-FMISO, 18F-FDG, 18F-FLT and the hypoxic selective 64Cu-ATSM in a rodent model of cancer
CS Dence, DE Ponde, MJ Welch, JS Lewis - Nuclear medicine and biology, 2008 - Elsevier
INTRODUCTION: Copper (II)-diacetyl-bis (N4-methylthiosemicarbazone), or Cu-ATSM, a
hypoxia imaging agent, has been shown to be predictive of response to traditional cancer …
hypoxia imaging agent, has been shown to be predictive of response to traditional cancer …
Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside
M Piert, HJ Machulla, M Picchio, G Reischl… - Journal of Nuclear …, 2005 - Soc Nuclear Med
The study was performed to compare the 18F-labeled nitroimidazole compound
fluoroazomycin arabinoside (18F-FAZA) with the standard hypoxia tracer fluoromisonidazole …
fluoroazomycin arabinoside (18F-FAZA) with the standard hypoxia tracer fluoromisonidazole …
Pathophysiologic correlation between 62Cu-ATSM and 18F-FDG in lung cancer
TG Lohith, T Kudo, Y Demura, Y Umeda… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The purpose of this study was to delineate the differences in intratumoral uptake and tracer
distribution of 62Cu-diacetyl-bis (N 4-methylthiosemicarbazone)(62Cu-ATSM), a well-known …
distribution of 62Cu-diacetyl-bis (N 4-methylthiosemicarbazone)(62Cu-ATSM), a well-known …
Imaging hypoxia in tumors
JR Ballinger - Seminars in nuclear medicine, 2001 - Elsevier
For many years, it has been known that hypoxia affects the response to radiotherapy in
human cancers. Hypoxic regions can develop as a tumor grows beyond the ability of its …
human cancers. Hypoxic regions can develop as a tumor grows beyond the ability of its …
Evaluation of62Cu labeled diacetyl-bis(N 4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer
N Takahashi, Y Fujibayashi, Y Yonekura… - Annals of nuclear …, 2000 - Springer
Abstract 62 Cu labeled diacetyl-bis (N 4-methylthiosemicarbazone)(62 Cu-ATSM) has been
proposed as a generator-produced, positron-emitting tracer for hypoxic tissue imaging. From …
proposed as a generator-produced, positron-emitting tracer for hypoxic tissue imaging. From …
Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2 …
M Busk, MR Horsman, S Jakobsen, S Keiding… - International Journal of …, 2008 - Elsevier
PURPOSE: Positron emission tomography (PET) allows noninvasive assessment of tumor
hypoxia; however the combination of low resolution and slow tracer clearance from …
hypoxia; however the combination of low resolution and slow tracer clearance from …
Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon …
Y Yoshii, T Furukawa, Y Kiyono, R Watanabe… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: 64Cu-diacetyl-bis (N4-methylthiosemicarbazone)(64Cu-ATSM) is an
imaging agent for positron emission tomography (PET) that targets hypoxic tumors. 64Cu …
imaging agent for positron emission tomography (PET) that targets hypoxic tumors. 64Cu …