The aim of this study was to develop the radiosyntheses of diastereomerically pure 6 R-and
6 S-3ʹ-aza-2ʹ-18F-fluoro-5-methyltetrahydrofolate (MTHF)(6 R-18F-1 and 6 S-18F-1) using …

The folate receptor (FR) has been identified as a valuable target for the imaging of cancer
and activated macrophages, involved in inflammatory and autoimmune diseases via …

The aim of this study was to identify a folate receptor-α (FRα)–selective PET agent
potentially suitable for the selection of patients who might profit from FRα-targeted therapies …

5-Methyltetrahydrofolate (5-MTHF), a reduced folate form, is the biologically active folate
involved in many different metabolic processes. To date, there are no studies available in …

The folate receptor is a proven target for folate-based diagnosis and treatment of cancer.
Several folic acid conjugates have been developed as radiopharmaceuticals, but a suitable …

Purpose The folate receptor (FR) is frequently overexpressed in a variety of tumor types and,
hence, an interesting target for radionuclide therapy. The aim of this study was to evaluate a …

Folic acid was linked regioselectively through its α-and γ-carboxyl groups to 4-
fluorobenzylamine (FBA), and the α-and γ-FBA-folate regioisomers were evaluated for their …

The folate receptor (FR) is upregulated in various cancer types (FR-α isoform) and in
activated macrophages (FR-β isoform) which are involved in inflammatory and autoimmune …

There is a need to develop more potent radiofluorinated folic acid conjugates for a better
visualization of folate receptors that overexpress on many human cancers. Due to the …

In an attempt to visualize folate receptors that over‐express on many cancers,[18F]‐
fluorobenzene and pyridine carbohydrazide‐folates were synthesized using two different …