In vitro and in vivo characterization of 2-deoxy-2-18F-fluoro-D-mannose as a tumor-imaging agent for PET

S Furumoto, R Shinbo, R Iwata… - Journal of Nuclear …, 2013 - Soc Nuclear Med
2-Deoxy-2-18F-fluoro-d-mannose (18F-FDM) is an 18F-labeled mannose derivative and a
stereoisomer of 18F-FDG. Our preliminary study demonstrated that 18F-FDM accumulated in …

Experimental study for cancer diagnosis with positron-labeled fluorinated glucose analogs: [18F]-2-fluoro-2-deoxy-D-mannose: A new tracer for cancer detection

H Fukuda, T Matsuzawa, Y Abe, S Endo… - European journal of …, 1982 - Springer
Abstract 18 F-2-fluoro-2-deoxy-D-glucose (18 F-FDG) and 18 F-2-fluoro-2-deoxy-D-
mannose (18 F-FDM) were tested as tumor diagnostic agents in a transplantable rat tumor …

Radiopharmacological evaluation of 6-deoxy-6-[18F] fluoro-D-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer

M Wuest, BJ Trayner, TN Grant, HS Jans… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: Several clinical studies have shown low or no expression of GLUT1 in
breast cancer patients, which may account for the low clinical specificity and sensitivity of 2 …

Simple and rapid radiosynthesis of N-18F-labeled glutamic acid as a hepatocellular carcinoma PET tracer

A Sun, S Liu, X Tang, D Nie, G Tang, Z Zhang… - Nuclear Medicine and …, 2017 - Elsevier
Introduction We have reported that N-(2-18 F-fluoropropionyl)-L-glutamate (18 F-FPGLU)
showed good tumor-to-background contrast and 18 F-FPGLU was prepared via complex …

Evaluation of F-18-labeled amino acid derivatives and [18F] FDG as PET probes in a brain tumor-bearing animal model

HE Wang, SY Wu, CW Chang, RS Liu… - Nuclear medicine and …, 2005 - Elsevier
2-Deoxy-2-[18F] fluoro-d-glucose ([18F] FDG) has been extensively used as positron
emission tomography (PET) tracer in clinical tumor imaging. This study compared the …

In vivo assessment of 6-deoxy-6-[18F] fluoro-D-galactose as a PET tracer for studying galactose metabolism

K Ishiwata, M Tomura, T Ido, R Iwata, J Itoh… - International Journal of …, 1989 - Elsevier
Abstract The potential of 6-deoxy-6-[18 F] fluoro-d-galactose (6-[18 F] FdGal) as an in vivo
tracer for studying galactose metabolism in tumors and liver was investigated. High uptake …

Biological evaluation of 2-fluoro-2-[123I] iodo-mannose (FIM): biological evaluation of FIM

G Matte, M Adam, D Lyster - Nuclear medicine and biology, 2001 - Elsevier
This paper describes the biodistribution of a radio-iodinated analog of fluorodeoxyglucose
(FDG). 123I-2-fluoro-2-iodo-mannose (FIM) was investigated as a potential single photon …

Synthesis and Preliminary Evaluation of 1‐[18F]Fluoro‐1‐deoxy‐2,5‐anhydro‐D‐mannitol as a PET Radiotracer for Breast Cancer Imaging

B Niu, X Wen, Z Jia, X Wu, W Guo… - Chinese Journal of …, 2013 - Wiley Online Library
[18F] Fluoro‐1‐deoxy‐2, 5‐anhydro‐D‐mannitol (3, 18F‐FDAM) has been synthesized in 6
steps starting from 2, 5‐anhydro‐D‐mannitol (2, 5‐AM) and evaluated as a new radiotracer …

Pioneering and fundamental achievements on the development of positron emission tomography (PET) in oncology

H Fukuda, K Kubota, T Matsuzawa - The Tohoku journal of …, 2013 - jstage.jst.go.jp
Positron emission tomography (PET) with 18 F-fluorodeoxyglucose (18 F-FDG), a glucose
analog, is widely used throughout the world as an indispensable imaging modality for the …

Effective Radiotherapy of Primary Tumors and Metastasis with 18F-2-Deoxy-2-Fluoro-D-Glucose in C57BL/6 Mice

V Caridad, M Arsenak, MJ Abad, R Martín… - Cancer biotherapy & …, 2008 - liebertpub.com
Introduction: The radiochemical 18F-2-deoxy-2-fluoro-D-glucose (18F-FDG), a positron
emitter, is taken up preferentially by malignant tumors with high metabolic rates. This …