Kinetic evaluation of [18F] MOZAT PET imaging in humans.
1698 Objectives: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
catalyzes the conversion of cortisone into active cortisol, a neuroendocrine stress hormone …
catalyzes the conversion of cortisone into active cortisol, a neuroendocrine stress hormone …
First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes enzymatic conversion of
cortisone into the stress hormone cortisol. This first-in-human brain imaging study …
cortisone into the stress hormone cortisol. This first-in-human brain imaging study …
First-in-human study of the 11β-hydroxysteroid dehydrogenase type 1 PET tracer [11C] AS2471907
580 Objectives The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
converts cortisone to cortisol. Inhibition of 11β-HSD1 may be a potential therapy for cognitive …
converts cortisone to cortisol. Inhibition of 11β-HSD1 may be a potential therapy for cognitive …
Synthesis and evaluation of a novel 18F-labeled radiotracer for imaging 11β-HSD1 in the brain
548 Objectives: The enzyme 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) converts
cortisone to cortisol, and controls a key pathway in the regulation of stress. As such it is …
cortisone to cortisol, and controls a key pathway in the regulation of stress. As such it is …
Liver and Brain Levels of 11β-hydroxysteroid Dehydrogenase Type 1 Enzyme in Obesity: Preliminary Results from PET Imaging Studies
2801 Introduction: Cortisol is known to promote adipocyte differentiation and maturation, and
prolonged exposure to excess cortisol contributes to development of obesity and metabolic …
prolonged exposure to excess cortisol contributes to development of obesity and metabolic …
Imaging the enzyme 11β-hydroxysteroid dehydrogenase type 1 with PET: evaluation of the novel radiotracer 11C-AS2471907 in human brain
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
Influence of Modeling Options on Kinetic Parameters for [18F] NOS PET Human Studies
Y Wu, JD Gallezot, J Reddin, M Naganawa, H Lee… - 2022 - Soc Nuclear Med
3182 Introduction: Tracer kinetic modeling is essential for accurate quantification of
physiological parameters and is critically important for novel tracers. Replication across …
physiological parameters and is critically important for novel tracers. Replication across …
Reduction of 11β-hydroxysteroid dehydrogenase type 1 enzyme levels with increasing body mass index: a Brain PET imaging study
1300 Objectives: The prevalence of obesity in the United States is over 30%, predisposing a
large portion of the population to metabolic diseases. Cortisol, a steroid hormone, promotes …
large portion of the population to metabolic diseases. Cortisol, a steroid hormone, promotes …
[PDF][PDF] Imaging the enzyme 11b-hydroxysteroid dehydrogenase type 1 with PET: evaluation of the novel radiotracer 11C-AS2471907 in human brain
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
Multi-compartment pharmacokinetic modeling of dynamic 18F-FMAU PET/CT in patients with brain lesions
H Jadvar, Y Ju, C Eng, J Ye, K Chen, A Azadikhah… - 2023 - Soc Nuclear Med
P747 Introduction: Brain neoplasms encompass a wide range of primary and metastatic
cancers. There is a significant unmet clinical regarding the accurate discrimination between …
cancers. There is a significant unmet clinical regarding the accurate discrimination between …