99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer

SM Hillier, KP Maresca, G Lu, RD Merkin… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and
small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent …

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with …

S Vallabhajosula, A Nikolopoulou… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a well-established target for developing
radiopharmaceuticals for imaging and therapy of prostate cancer (PCa). We have recently …

Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer

CA Foss, RC Mease, H Fan, Y Wang, HT Ravert… - Clinical cancer …, 2005 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is a cell surface protein that is
overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our …

Clinical translation of a PSMA inhibitor for 99mTc-based SPECT

G Ferro-Flores, M Luna-Gutiérrez… - Nuclear medicine and …, 2017 - Elsevier
Background Prostate-specific membrane antigen (PSMA) is highly over-expressed in
advanced prostate cancers. 68 Ga-labeled PSMA inhibitors (iPSMA) are currently used for …

Synthesis and evaluation of technetium-99m-and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA)

SR Banerjee, CA Foss, M Castanares… - Journal of medicinal …, 2008 - ACS Publications
The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable
target for imaging and therapy of cancer. We prepared seven 99mTc/Re-labeled compounds …

Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate …

SM Hillier, KP Maresca, FJ Femia, JC Marquis… - Cancer research, 2009 - AACR
Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate
epithelium and is highly up-regulated in prostate cancer. We previously reported a series of …

[HTML][HTML] Towards personalized treatment of prostate cancer: PSMA I&T, a promising prostate-specific membrane antigen-targeted theranostic agent

KLS Chatalic, S Heskamp, M Konijnenberg… - Theranostics, 2016 - ncbi.nlm.nih.gov
Prostate-specific membrane antigen (PSMA) is a well-established target for nuclear imaging
and therapy of prostate cancer (PCa). Radiolabeled small-molecule PSMA inhibitors are …

Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents

SA Kularatne, Z Zhou, J Yang, CB Post… - Molecular …, 2009 - ACS Publications
The high mortality and financial burden associated with prostate cancer can be partly
attributed to a lack of sensitive screening methods for detection and staging of the disease …

Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen–targeted imaging agent for prostate cancer

SE Lapi, H Wahnishe, D Pham, LY Wu… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a transmembrane protein commonly found
on the surface of late-stage and metastatic prostate cancer and a well-known imaging …

Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand

SA Kularatne, K Wang, HKR Santhapuram… - Molecular …, 2009 - ACS Publications
Prostate cancer (PCa) is a major cause of mortality and morbidity in Western society today.
Current methods for detecting PCa are limited, leaving most early malignancies …