Previously, we reported a small-molecular-weight peptide, single amino acid chelae
(99mTc)-conjugated phosphatidylserine-binding peptide (SAAC (99mTc)-PSBP-6), with high …

Molecular imaging of programmed cell death (apoptosis) in vivo is an innovative strategy for
early assessment of treatment response and treatment efficacy in cancer patients …

An immunoPET imaging probe for the detection of phosphatidylserine was developed and
tested in animal models of human cancer treated with pro-apoptotic therapy. We …

Molecular imaging of biological processes may allow detection of therapy effects before the
tumor is reduced in size. The most frequently used PET tracer in oncology, 2-[18F] fluoro-2 …

Purpose Early after therapy, 2-deoxy-2-[18 F] fluoro-d-glucose ([18 F] FDG) imaging is not
always reliable due to the influx of inflammatory cells while apoptosis imaging offers a direct …

Purpose We have previously developed the caspase-based radiotracer, 18 F-ICMT-11, for
PET imaging to monitor treatment response. We further validated 18 F-ICMT-11 specificity in …

Introduction Radiolabeled phosphatidylserine (PS)-binding peptides represent an
innovative strategy for molecular imaging of apoptosis with positron emission tomography …

The early assessment of a solid tumor's response to conventional or new drug therapy to
complement or replace current RECIST (or other clinical) criteria remains an elusive goal …

Purpose In vivo detection of apoptosis is a diagnostic tool with potential clinical applications
in cardiology and oncology. Radiolabeled annexin-V (anxV) is an ideal probe for in vivo …

Purpose A novel caspase-3 substrate-based probe [18 F]-CP18 was evaluated as an in vivo
positron emission tomography (PET) imaging agent for monitoring apoptosis in tumors …