Time course of striatal dopamine transporter loss in striatal 6-hydroxydopamine rat model of Parkinson's disease: A study with [123I] beta-CIT and small animal SPECT

SH Moon, SE Kim, JY Son, IS Jung, SJ Kim, JS Kim… - 2010 - Soc Nuclear Med
1758 Objectives Dopamine transporter (DAT) imaging in animal models of Parkinson's
disease (PD) is an important tool for studying pathogenic mechanisms and therapeutic …

In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET

V Sossi, K Dinelle, S Jivan, K Fischer… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Dopamine transporter (DAT) function is altered by many neurodegenerative diseases. For
instance, in Parkinson disease DAT density has been shown to decrease in early disease …

Differential alterations of dopamine transporter in the striatum and midbrain in patients with parkinsonian syndrome

MC Matesan, DJ Cross, DH Lewis… - Clinical Nuclear …, 2015 - journals.lww.com
Objectives Differential vulnerabilities of subregional dopamine neurons have been
suggested in movement disorders such as idiopathic Parkinson disease. In this study, we …

Correlations between dopamine transporter density measured by 123I-FP-CIT SPECT and regional gray matter volume in Parkinson's disease

T Maekawa, N Sato, M Ota, A Sugiyama… - Japanese Journal of …, 2017 - Springer
Purpose Parkinson's disease (PD) is caused by a selective degeneration of dopamine
neurons. The relationship between dopamine transporter (DAT) density and gray matter …

Pinhole SPECT imaging of dopamine transporters correlates with dopamine transporter immunohistochemical analysis in the MPTP mouse model of Parkinson's …

G Andringa, B Drukarch, JGJM Bol, K de Bruin… - Neuroimage, 2005 - Elsevier
The in vivo analysis of dopaminergic degeneration in animal models of Parkinson's disease
(PD), using pinhole single photon emission computed tomography (SPECT), ideally should …

Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson's disease

WJ Hwang, WJ Yao, SP Wey… - Journal of nuclear …, 2004 - Soc Nuclear Med
Functional brain imaging targeting the presynaptic dopamine nerve terminal of the
nigrostriatal system has been used for monitoring disease progression and evaluating …

[123I]β-CIT SPECT imaging assessment of the rate of Parkinson's disease progression

K Marek, R Innis, C Van Dyck, B Fussell, M Early… - Neurology, 2001 - AAN Enterprises
Background:[123I] β-CIT and SPECT imaging of the dopamine transporter is a sensitive
biomarker of PD onset and severity. Objective: In this study, the authors examine the change …

Comparison between the decrease of dopamine transporter and that of L‐DOPA uptake for detection of early to advanced stage of Parkinson's disease in animal …

Y Ito, M Fujita, S Shimada, Y Watanabe, T Okada… - Synapse, 1999 - Wiley Online Library
Early diagnosis of Parkinson's disease (PD) is important for the potential application of
neuroprotective therapies. The purpose of this study was to assess the detection of the early …

Loss of dopamine transporter binding in Parkinson's disease follows a single exponential rather than linear decline

J Schwarz, A Storch, W Koch, O Pogarell… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Imaging of l-dopa uptake or dopamine transporter binding can monitor the progression of
Parkinson's disease. Most follow-up studies have provided data best fitted by a linear …

Striatal dopamine transporter binding in early to moderately advanced Parkinson's disease: monitoring of disease progression over 2 years

M Chouker, K Tatsch, R Linke, O Pogarell… - Nuclear medicine …, 2001 - journals.lww.com
Imaging of striatal dopamine transporter binding allows differentiation between patients with
Parkinson's disease and controls. We investigated the use of this technique to monitor …