62 Objectives Early diagnosis is a major challenges for rheumatology, and activated
macrophages play an important roles in an early rheumatoid arthritis (RA) pathogenesis …

Activated macrophages have been known to play pivotal roles in the pathogenesis of
rheumatoid arthritis (RA). 18F-FEDAC (N-benzyl-N-methyl-2-[7, 8-dihydro-7-(2-18F …

PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific
means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of …

335 Objectives: To prepare a novel radiolabeled TSPO ligand 2-(5, 7-Diethyl-2-(4-(2-[18 F]
fluoroethoxy) phenyl) pyrazolo [1, 5-a] pyrimidin-3-yl)-N, N-diethylacetamide (18 F …

CIA) was established by intradermal injection of emulsified adjuvant and type II collagen in
DBA1 mice. After ETN, MTX or vehicle treatments, 18F-FEDAC and 18F-FDG PET scans …

Rheumatoid arthritis (RA) is a chronic disease with systemic inflammation resulting in
destruction of multiple articular cartilages and bones. Activated macrophage plays a pivotal …

Background Activated macrophages infiltrate synovial tissue in early stages of rheumatoid
arthritis (RA). Therefore, macrophage targeting is attractive for early diagnostics of RA. The …

Abstract Objectives Translocator protein 18 kDa (TSPO) positron emission tomography
(PET) can be harnessed for the non-invasive detection of macrophage-driven …

Purpose The translocator protein (18 kDa)(TSPO) is highly expressed on the bronchial and
bronchiole epithelium, submucosal glands in intrapulmonary bronchi, pneumocytes and …

Positron emission tomography (PET) imaging of the translocator 18 kDa protein (TSPO) with
radioligands has become an effective means of research in peripheral inflammatory …