The aim of this SPECT study was to investigate the effects of donepezil on regional cerebral
blood flow (rCBF) in patients with mild to moderate Alzheimer's disease (AD) using statistical …

Introduction Donepezil, an acetylcholinesterase inhibitor, has been reported to have an
effect that improves cerebral blood flow (CBF) alongside its primary effect on memory …

Objective The objective of this study was to elucidate the relationship between the effects of
donepezil hydrochloride (donepezil) and cerebral blood flow, and to evaluate the usefulness …

Alzheimer's disease is associated with a loss in presynaptic cholinergic function. It has been
suggested that cholinergic inhibitors such as donepezil hydrochloride (Donepezil) could …

ABSTRACT Background and Purpose. Treatment with acetylcholinesterase inhibitors
(AchEIs) is beneficial for patients with Alzheimer's disease (AD). But the clinical response …

We attempted to identify the characteristic patterns in regional cerebral blood flow (rCBF) of
patients with Alzheimer's disease who responded to donepezil therapy. Sixty-one patients …

Background: The recent introduction of acetylcholinesterase inhibitors (AChEIs) therapy for
Alzheimer's Disease (AD) has led to the need to assess the brain's response to the therapy …

Objective We performed combined studies of magnetic resonance imaging (MRI) analysis of
the substantia innominata and single photon emission CT (SPECT) measurement of …

Transient cognitive and behavioral stabilization of patients with Alzheimer's disease (AD) is
the main goal of long-term acetylcholinesterase inhibitor (AChEI) therapy, but response to …

The aim of this SPECT study was to determine the initial abnormality and longitudinal
changes in regional cerebral blood flow (rCBF) in early Alzheimer's disease (AD) using …