Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2: 2395, with C-terminally engineered cysteine
S Ahlgren, H Wållberg, TA Tran… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The detection of human epidermal growth factor receptor type 2 (HER2) expression in
malignant tumors provides important information influencing patient management …
malignant tumors provides important information influencing patient management …
Kit formulation for 99mTc-labeling of recombinant anti-HER2 Affibody molecules with a C-terminally engineered cysteine
S Ahlgren, K Andersson, V Tolmachev - Nuclear medicine and biology, 2010 - Elsevier
INTRODUCTION: Molecular imaging of human epidermal growth factor receptor type 2
(HER2)-expression in malignant tumors provides potentially important information for patient …
(HER2)-expression in malignant tumors provides potentially important information for patient …
HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule
H Wållberg, J Grafström, Q Cheng, L Lu… - Journal of Nuclear …, 2012 - Soc Nuclear Med
A rapid, reliable method for distinguishing tumors or metastases that overexpress human
epidermal growth factor receptor 2 (HER2) from those that do not is highly desired for …
epidermal growth factor receptor 2 (HER2) from those that do not is highly desired for …
Molecular design and optimization of 99mTc-labeled recombinant affibody molecules improves their biodistribution and imaging properties
Affibody molecules are a recently developed class of targeting proteins based on a
nonimmunoglobulin scaffold. The small size (7 kDa) and subnanomolar affinity of Affibody …
nonimmunoglobulin scaffold. The small size (7 kDa) and subnanomolar affinity of Affibody …
188Re-ZHER2: V2, a promising affibody-based targeting agent against HER2-expressing tumors: preclinical assessment
M Altai, H Wållberg, H Honarvar, J Strand… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Affibody molecules are small (7 kDa) nonimmunoglobulin scaffold proteins with favorable
tumor-targeting properties. Studies concerning the influence of chelators on biodistribution …
tumor-targeting properties. Studies concerning the influence of chelators on biodistribution …
Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence
Purpose Expression of human epidermal growth factor receptor type 2 (HER2) in malignant
tumours possesses well-documented prognostic and predictive value. Non-invasive imaging …
tumours possesses well-documented prognostic and predictive value. Non-invasive imaging …
Affibody-mediated tumour targeting of HER-2 expressing xenografts in mice
AC Steffen, A Orlova, M Wikman, FY Nilsson… - European journal of …, 2006 - Springer
Purpose Targeted delivery of radionuclides for diagnostic and therapeutic applications has
until recently largely been limited to receptor ligands, antibodies and antibody-derived …
until recently largely been limited to receptor ligands, antibodies and antibody-derived …
99mTc-maEEE-ZHER2:342, an Affibody Molecule-Based Tracer for the Detection of HER2 Expression in Malignant Tumors
Detection of HER2-overexpression in tumors and metastases is important for the selection of
patients who will benefit from trastuzumab treatment. Earlier investigations showed …
patients who will benefit from trastuzumab treatment. Earlier investigations showed …
Evaluation of the first 44Sc-labeled Affibody molecule for imaging of HER2-expressing tumors
H Honarvar, C Müller, S Cohrs, S Haller… - Nuclear medicine and …, 2017 - Elsevier
Introduction Affibody molecules are small (58 amino acids) high-affinity proteins based on a
tri-helix non-immunoglobulin scaffold. A clinical study has demonstrated that PET imaging …
tri-helix non-immunoglobulin scaffold. A clinical study has demonstrated that PET imaging …
Imaging of HER3-expressing xenografts in mice using a 99mTc(CO)3-HEHEHE-ZHER3:08699 affibody molecule
Purpose Human epidermal growth factor receptor type 3 (HER3) is a transmembrane
receptor tyrosine kinase belonging to the HER (ErbB) receptor family. Membranous …
receptor tyrosine kinase belonging to the HER (ErbB) receptor family. Membranous …
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