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α-versus β-emitting radionuclides for pretargeted radioimmunotherapy of carcinoembryonic antigen–expressing human colon cancer xenografts

S Heskamp, R Hernandez… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Pretargeted radioimmunotherapy (PRIT) with the β-emitting radionuclide 177Lu is an
attractive approach to treat carcinoembryonic antigen (CEA)–expressing tumors. The …
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Alpha-versus beta-emitting radionuclides for pretargeted radioimmunotherapy of CEA-expressing human colon cancer xenografts

S Heskamp, R Hernandez… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Rational: Pretargeted radionuclide therapy (PRIT) with the beta-emitting radionuclide 177 Lu
is an attractive approach to treat CEA-expressing tumors. The therapeutic efficacy of PRIT …
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Pretargeted 177Lu radioimmunotherapy of carcinoembryonic antigen–expressing human colonic tumors in mice

R Schoffelen, WTA van der Graaf… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Pretargeted radioimmunotherapy (PRIT) with bispecific antibodies in combination with a
radiolabeled peptide reduces the radiation dose to normal tissues, especially the bone …
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Quantitative immuno-SPECT monitoring of pretargeted radioimmunotherapy with a bispecific antibody in an intraperitoneal nude mouse model of human colon cancer

R Schoffelen, WTA van der Graaf… - Journal of Nuclear …, 2012 - Soc Nuclear Med
The prospects for using pretargeted immuno-SPECT to monitor the response to pretargeted
radioimmunotherapy were examined. In this study, a bispecific anticarcinoembryonic …
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Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG …

SM Cheal, H Xu, H Guo, S Lee, B Punzalan… - European journal of …, 2016 - Springer
Purpose GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after
huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) …
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Curative multicycle radioimmunotherapy monitored by quantitative SPECT/CT-based theranostics, using bispecific antibody pretargeting strategy in colorectal cancer

SM Cheal, EK Fung, M Patel, H Xu, H Guo… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Radioimmunotherapy of solid tumors using antibody-targeted radionuclides has been
limited by low therapeutic indices (TIs). We recently reported a novel 3-step pretargeted …
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[PDF][PDF] Pretargeted radioimmunotherapy of human colorectal xenografts with bispecific antibody and 131I-labeled bivalent hapten

E Gautherot, E Rouvier, L Daniel, E Loucif… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Methods: A totalof 6 groupsoftumor-bearingmiceweretreated using anticarcinoembryonic
antigen (CEA) x anti-diethylenetn amine pentaacetic acid (DTPA)-ln bispecific antibody (BsF …
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Two-step targeting of xenografted colon carcinoma using a bispecific antibody and 188Re-labeled bivalent hapten: biodistribution and dosimetry studies

JF Gestin, A Loussouarn, M Bardiès… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Radioimmunotherapy (RIT) is currently being considered for the treatment of solid tumors.
Although results have been encouraging for pretargeted 131I RIT with the affinity …
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Advantage of a residualizing iodine radiolabel in the therapy of a colon cancer xenograft targeted with an anticarcinoembryonic antigen monoclonal antibody

R Stein, SV Govindan, M Hayes, GL Griffiths… - Clinical cancer …, 2005 - AACR
Purpose: A disadvantage of conventionally radioiodinated monoclonal antibodies (mAb) for
cancer therapy is the short retention time of the radionuclide within target cells. To address …
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Radioimmunotherapy of Human Colon Cancer Xenografts with 131I-Labeled Anti-CEA Monoclonal Antibody

Z Liu, C Jin, Z Yu, J Zhang, Y Liu, H Zhao… - Bioconjugate …, 2010 - ACS Publications
Radioimmunotherapy (RIT) is a promising approach for the treatment of a wide variety of
malignancies. The aim of this study was to investigate the therapeutic efficacy of 131I …
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