74 Objectives: Synaptic development begins mid-gestation in the nonhuman primate (NHP),
where synaptic density increases to exceed the level of the adult at the time of birth, and …

578 Objectives: For noninvasive quantification of PET images by reference region methods,
a region in which the total radioligand uptake is representative of the nondisplaceable (ie …

112 Introduction: In vivo measurements of synaptic density in the spinal cord (SC) can
provide benefits in the study of conditions such as SC injury 1 and amyotrophic lateral …

1800 Objectives We recently developed 11 C-UCB-J as a promising PET ligand for
quantitative measurement of synaptic vesicle glycoprotein 2A (SV2A) in monkeys and …

77 Introduction: The PET radioligand 11 C‑UCB‑J binds to the synaptic vesicle glycoprotein
2 (SV2A) to enable in vivo quantification of synaptic density 1, 2. In previous work, we found …

Purpose Exploring synaptic density changes during brain growth is crucial to understanding
brain development. Previous studies in nonhuman primates report a rapid increase in …

77 Objectives: The recently developed synaptic vesicle glycoprotein 2A (SV2A) PET tracer,
11 C-UCB-J, has demonstrated excellent properties for imaging synaptic density [1]. In vivo …

Loss of synapses and neurons is the primary feature of neurodegenerative pathology. The
development of novel, diseasemodifying medication requires the ability to identify patients in …

Positron emission tomography (PET) is a functional imaging modality in which radioactive
ligands are used to target physiological functions, including metabolism or receptor …

576 Objectives: 11 C-UCB-J is a PET radioligand that targets the synaptic vesicle
glycoprotein 2A (SV2A) and can potentially be used to estimate synaptic density in humans …