Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF–induced thermoablative therapy for human breast cancer in mice
SJ DeNardo, GL DeNardo, A Natarajan… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Antibody (mAb)-linked iron oxide nanoparticles (bioprobes) provide the opportunity to
develop tumor specific thermal therapy (Rx) for metastatic cancer when inductively heated …
develop tumor specific thermal therapy (Rx) for metastatic cancer when inductively heated …
Development of Tumor Targeting Bioprobes (111In-Chimeric L6 Monoclonal Antibody Nanoparticles) for Alternating Magnetic Field Cancer Therapy
SJ DeNardo, GL DeNardo, LA Miers, A Natarajan… - Clinical cancer …, 2005 - AACR
Abstract Objectives: 111In-chimeric L6 (ChL6) monoclonal antibody (mAb)–linked iron oxide
nanoparticle (bioprobes) pharmacokinetics, tumor uptake, and the therapeutic effect of …
nanoparticle (bioprobes) pharmacokinetics, tumor uptake, and the therapeutic effect of …
Biocompatible nanoclusters with high heating efficiency for systemically delivered magnetic hyperthermia
Despite its promising therapeutic potential, nanoparticle-mediated magnetic hyperthermia is
currently limited to the treatment of localized and relatively accessible cancer tumors …
currently limited to the treatment of localized and relatively accessible cancer tumors …
[HTML][HTML] High therapeutic efficiency of magnetic hyperthermia in xenograft models achieved with moderate temperature dosages in the tumor area
S Kossatz, R Ludwig, H Dähring, V Ettelt… - Pharmaceutical …, 2014 - Springer
Purpose Tumor cells can be effectively inactivated by heating mediated by magnetic
nanoparticles. However, optimized nanomaterials to supply thermal stress inside the tumor …
nanoparticles. However, optimized nanomaterials to supply thermal stress inside the tumor …
Development of multivalent radioimmunonanoparticles for cancer imaging and therapy
A Natarajan, CY Xiong, C Gruettner… - Cancer biotherapy & …, 2008 - liebertpub.com
Background: Noninvasive, focused hyperthermia can be achieved by using an externally
applied alternating magnetic field (AMF) if effective concentrations of nanoparticles can be …
applied alternating magnetic field (AMF) if effective concentrations of nanoparticles can be …
Rapid tumor inhibition via magnetic hyperthermia regulated by caspase 3 with time-dependent clearance of iron oxide nanoparticles
Among conventional cancer therapies, radio-frequency magnetic hyperthermia (MHT) has
widely been investigated for use with magnetic nanoparticles (MNPs). However, the majority …
widely been investigated for use with magnetic nanoparticles (MNPs). However, the majority …
[HTML][HTML] Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment
Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging
(MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH) …
(MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH) …
[HTML][HTML] Biologically targeted magnetic hyperthermia: Potential and limitations
Hyperthermia, the mild elevation of temperature to 40–43° C, can induce cancer cell death
and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full …
and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full …
[HTML][HTML] Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug …
Introduction Tumor cells can effectively be killed by heat, eg by using magnetic
hyperthermia. The main challenge in the field, however, is the generation of therapeutic …
hyperthermia. The main challenge in the field, however, is the generation of therapeutic …
Physical and biological properties of 5-fluorouracil polymer-coated magnetite nanographene oxide as a new thermosensitizer for alternative magnetic hyperthermia …
This study reports a new procedure for utilizing 5-fluorouracil (5-Fu)-loaded
polycaprolactone (PCL)/chitosan-covered magnetite nanographene oxide (5 …
polycaprolactone (PCL)/chitosan-covered magnetite nanographene oxide (5 …