The thrombus localizing properties of indium-111-recombinant tissue plasminogen activator
(l~ lln. rt_pA) have been investigated in an effort to achieve prompt and accurate detection of …

The in vitro functional properties of recombinant tissue plasminogen activator (rt-PA), its
biodistribution in mice, and its pharmacokinetics and clot localization properties in dogs …

Although radiolabeled fibrinogen has been used successfully for detection of thromboemboli
by imaging, plasminogen activators offer the advantage of clot detection after active fibrin …

In vivo distribution of Tc-99m labeled recombinant tissue-type plasminogen activator (Tc-
99m-rt-PA) was studied in control rats and thrombus-bearing rats. To compare fibrin binding …

Tissue-type plasminogen activator (t-PA) which has a high affinity for fibrin in the clot, was
labeled with 131 I by the iodogen method, and its binding to de-endothelialized lesions in …

Tissue-type plasminogen activator (t-PA) is a thrombolytic agent that directly binds to fibrin
formed in clots. In terms of radiolabeling and nuclear imaging, t-PA has several advantages …

Our previous studies demonstrated that 99m Tc labeled recombinant tissue plasminogen
activator (rt-PA) retained high affinity with fibrin in vitro but showed unexpectedly low uptake …

Prompt detection of acute thrombosis and its response to treatment with thrombolytic agents
generally require angiography. Scintigraphic approaches with labeled antibodies to or …

BACKGROUND Contemporary cardiovascular practice relies increasingly on thrombolysis
as a therapeutic modality. Its optimal use requires prompt, noninvasive delineation of …

MATERIALS AND METHODS Isolation of canine plasminogen. Canine plasmino gen was
isolated from fresh dog plasma by the affinity chromatography technique on a sepharose …