1008 Purpose: 18 F-FP-R 0 1-MG-F2 is a novel cystine knot peptide (knottin) PET tracer that
selectively binds to human integrin α v β 6. This integrin cell surface receptor is over …

Purpose A novel cystine-knot peptide–based PET radiopharmaceutical, 18 F-FP-R 0 1-MG-
F2 (knottin), was developed to selectively bind to human integrin α v β 6 which is …

Integrin αvβ6 is a cell surface receptor minimally expressed by healthy tissue but elevated in
lung, colon, skin, ovarian, cervical, and pancreatic cancers. A molecular PET agent for …

Purpose: Cystine knot (knottin) peptides, engineered to bind with high affinity to integrin
receptors, have shown promise as molecular imaging agents in living subjects. The aim of …

A divalent knottin containing two separate integrin binding epitopes (RGD) in the adjacent
loops, 3-4A, was recently developed and reported in our previous publication. In the current …

Knottins are small constrained polypeptides that share a common disulfide-bonded
framework and a triple-stranded β-sheet fold. Previously, directed evolution of the Ecballium …

We have determined the ability of PET with the thymidine analog 3′-deoxy-3′-18F-
fluorothymidine (FLT) to detect pancreatic cancer and to differentiate malignant from benign …

Integrin αvβ6 has been considered as a promising biomarker for lung cancer, and its
expression is often related to poor prognosis. An αvβ6-binding cystine knot peptide R01-MG …

1746 Objectives Evaluation of the test performance of PET with the proliferation marker FLT
compared to FDG for detection of pancreatic cancer. Methods In this ongoing clinical trial, 27 …

Introduction Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
malignant neoplasms, as many cases go undetected until they reach an advanced stage …