[18F] PTV-F1 PET for OATP Transporter Imaging of the Liver.-Preclinical and Phase I Clinical Study
R Nishii, S Kagawa, T Higashi, H Yamauchi, H Kimura… - 2015 - Soc Nuclear Med
1079 Objectives [18 F] PTV-F1 is a potential tracer for the quantitative evaluation of OATP
transporter of the liver. The aim of this study was to assess the feasibility of [18 F] PTV-F1 …
transporter of the liver. The aim of this study was to assess the feasibility of [18 F] PTV-F1 …
Comparison of [18F] PTV-F1 and [18F] pitavastatin as a PET probe for evaluation of hepatic organic anion transporting polypeptides function
Y Yagi, H Kimura, K Arimitsu, H Yasui, M Ono, H Saji - 2018 - Soc Nuclear Med
334 Objectives: The liver plays an important role in the excretion of xenobiotics, including
many kinds of drugs, and various transporters and metabolizing enzymes are involved in its …
many kinds of drugs, and various transporters and metabolizing enzymes are involved in its …
Development of [18F] Pitavastatin for the evaluation of in vivo function of organic anion transporting peptide
7 Objectives The liver plays an important role in the excretion of xenobiotics, including many
kinds of drugs, and various transporters and metabolizing enzymes are involved in the …
kinds of drugs, and various transporters and metabolizing enzymes are involved in the …
PET imaging–based evaluation of hepatobiliary transport in humans with (15R)-11C-TIC-Me
T Takashima, S Kitamura, Y Wada… - Journal of Nuclear …, 2012 - Soc Nuclear Med
It is well accepted that drug transporters play a pivotal role in hepatobiliary excretion of
anionic drugs, in which drug–drug interactions and genetic polymorphisms are known to …
anionic drugs, in which drug–drug interactions and genetic polymorphisms are known to …
Quantification of hepatic and extrahepatic OATP function using whole-body dynamic (11) C-glyburide PET imaging
S Marie, S Stute, S Goutal, W Saba… - European Journal of …, 2018 - inis.iaea.org
[en] Complete text of publication follows: Aim: Organic Anion-Transporting Polypeptides
(OATP) transporters expressed by hepatocytes are major determinants of the liver uptake …
(OATP) transporters expressed by hepatocytes are major determinants of the liver uptake …
Validation of hepatobiliary transport PET imaging in liver function assessment: Evaluation of 3β-[18F] FCA in mouse models of liver disease
S De Lombaerde, L Devisscher, J Verhoeven… - Nuclear Medicine and …, 2019 - Elsevier
Recently, our research group reported on the development of 3β-[18 F] Fluorocholic acid (3β-
[18 F] FCA), a 18 F labeled bile acid to detect drug interference with the bile acid …
[18 F] FCA), a 18 F labeled bile acid to detect drug interference with the bile acid …
Evaluation of transporter-mediated hepatobiliary transport of newly developed ¹⁸F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging
木村， 小野， 中本 - Drug Metabolism and Pharmacokinetics, 2019 - cir.nii.ac.jp
抄録 Quantitative evaluations of the functions of uptake and efflux transporters directly in vivo
is desired to understand an efficient hepatobiliary transport of substrate drugs. Pitavastatin is …
is desired to understand an efficient hepatobiliary transport of substrate drugs. Pitavastatin is …
Preclinical in vivo and in vitro comparison of the translocator protein PET ligands [18F]PBR102 and [18F]PBR111
S Eberl, A Katsifis, MA Peyronneau, L Wen… - European journal of …, 2017 - Springer
Purpose To determine the metabolic profiles of the translocator protein ligands PBR102 and
PBR111 in rat and human microsomes and compare their in vivo binding and metabolite …
PBR111 in rat and human microsomes and compare their in vivo binding and metabolite …
Radiation dosimetry on 18F-VAT in human
R Laforest, H Lui, J HUssain, K Cummings, J Perlmutter… - 2018 - Soc Nuclear Med
1002 Objectives: bjective: We previously reported based on PET imaging in nonhuman
primates human the radiation dosimetry estimates for [18F]-VAT [1], a novel radiotracer for …
primates human the radiation dosimetry estimates for [18F]-VAT [1], a novel radiotracer for …
Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging
Quantitative evaluations of the functions of uptake and efflux transporters directly in vivo is
desired to understand an efficient hepatobiliary transport of substrate drugs. Pitavastatin is a …
desired to understand an efficient hepatobiliary transport of substrate drugs. Pitavastatin is a …