211At— and 131l—Labeled Bisphosphonates with High Page 1 211At— and 131l—Labeled
Bisphosphonates with High In Vivo Stability and Bone Accumulation Roy H. Larsen, Kristin M …

Two new bisphosphonates have been examined for their ability to bind 188Re and deliver it
selectively to bone. The bisphosphonates are prototype compounds with potential to deliver …

A method is described for preparing 211At-and radioiodinated amidobisphosphonates. The
active esters N-succinimidyl 3-(tri-methylstannyl) benzoate (ATE) and N-succinimidyl 5-(tri …

MATERIALS AND METHODS Ethylenediaminetetra(methylene phosphonic) acid (an analog
of EDTA, herein called EDTMP), hexamethylenediaminetetra (methylene phosphonic) acid …

Arylalkylidenebisphosphonates labeled with nca [125I or 131I] have been synthesized and
their biological function investigated. The label was attached to the aromatic group in high …

The blood clearance of all current bone-seeking radiopharmaceuticals is biexponential
during the first four hours after injection. Exponent I represents bone uptake and its …

A comprehensive review on technetium chemistry and technetium radiopharmaceuticals
was published by Deutsch et al.(1983) and the chemistry of technetium in its IV states was …

To develop a radiopharmaceutical for the palliation of painful bone metastases based on the
concept of bifunctional radiopharmaceuticals, we designed a bisphosphonate derivative …

Objective: Disodium cycloheptylaminomethylenediphosphonate monohydrate (incadronate
disodium) is a third-generation bisphosphonate compound which potently inhibits bone …

To develop a radiopharmaceutical for the palliation of painful bone metastases based on the
concept of bifunctional radiopharmaceuticals, we synthesized a bisphosphonate derivative …