FAPI PET/CT: will it end the hegemony of 18F-FDG in oncology?
RJ Hicks, PJ Roselt, KG Kallur, RW Tothill… - Journal of Nuclear …, 2021 - Soc Nuclear Med
For over 40 years, 18F-FDG has been the dominant PET tracer in neurology, cardiology,
inflammatory diseases, and, most particularly, oncology. Combined with the ability to …
inflammatory diseases, and, most particularly, oncology. Combined with the ability to …
68Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer
C Kratochwil, P Flechsig, T Lindner… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The recent development of quinoline-based PET tracers that act as fibroblast-activation-
protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …
protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …
[HTML][HTML] Fibroblast-activated protein inhibitor PET/CT: cancer diagnosis and management
S Kuyumcu, Y Sanli, RM Subramaniam - Frontiers in oncology, 2021 - frontiersin.org
Fibroblast activation protein (FAP), overexpressed on cancer-associated fibroblasts (CAF), is
a novel target for molecular imaging of various tumors. Recently, the development of several …
a novel target for molecular imaging of various tumors. Recently, the development of several …
FAPI PET: fibroblast activation protein inhibitor use in oncologic and nononcologic disease
Y Mori, K Dendl, J Cardinale, C Kratochwil, FL Giesel… - Radiology, 2023 - pubs.rsna.org
Gallium 68 (68Ga)–labeled fibroblast activation protein (FAP) inhibitor (FAPI) PET is based
on the molecular targeting of the FAP, which is known to be highly expressed in the major …
on the molecular targeting of the FAP, which is known to be highly expressed in the major …
[CITATION][C] Unparalleled contribution of 18F-FDG PET to medicine over 3 decades
S Basu, A Alavi - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Since the introduction of 18F-FDG in 1976 (1)(Figs. 1–2), the last 3 decades have witnessed
a revolution in medical imaging. The widespread use of 18F-FDG PET as a molecular probe …
a revolution in medical imaging. The widespread use of 18F-FDG PET as a molecular probe …
68Ga-FAPI PET/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers
FL Giesel, C Kratochwil, T Lindner… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts of
several tumor entities. The recent development of quinoline-based PET tracers that act as …
several tumor entities. The recent development of quinoline-based PET tracers that act as …
Radiation dosimetry and biodistribution of 68Ga-FAPI-46 PET imaging in cancer patients
Targeting cancer-associated fibroblasts (CAFs) has become an attractive goal for diagnostic
imaging and therapy because they can constitute as much as 90% of a tumor mass. The …
imaging and therapy because they can constitute as much as 90% of a tumor mass. The …
[HTML][HTML] Head-to-head intra-individual comparison of biodistribution and tumor uptake of 68Ga-FAPI and 18F-FDG PET/CT in cancer patients
FL Giesel, C Kratochwil, J Schlittenhardt… - European journal of …, 2021 - Springer
Purpose FAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for
PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The …
PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The …
[HTML][HTML] FAPI-avid nonmalignant PET/CT findings: an expedited systematic review
M Bentestuen, N Al-Obaydi, HD Zacho - Seminars in Nuclear Medicine, 2023 - Elsevier
Fibroblast activation protein inhibitor (FAPI) is a promising tracer in oncologic positron
emission tomography/computed tomography (PET/CT). Numerous studies have …
emission tomography/computed tomography (PET/CT). Numerous studies have …
Targeting fibroblast activation protein: radiosynthesis and preclinical evaluation of an 18F-labeled FAP inhibitor
J Toms, J Kogler, S Maschauer, C Daniel… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Fibroblast activation protein (FAP) has emerged as an interesting molecular target used in
the imaging and therapy of various types of cancers. 68Ga-labeled chelator-linked FAP …
the imaging and therapy of various types of cancers. 68Ga-labeled chelator-linked FAP …