Robust estimation of the 18F-flurpiridaz retention fraction for quantification of myocardial blood flow in CAD patients

R DeKemp, KY Wu, N Kaps, J Lazewatsky… - 2020 - Soc Nuclear Med
221 Objectives: 18F-flurpiridaz (FPZ) is a new PET perfusion tracer with close to 100%
extraction fraction during the first-pass transit through the coronary circulation. High tracer …

Simplified quantification of myocardial flow reserve with flurpiridaz F 18: validation with microspheres in a pig model

HM Sherif, SG Nekolla, A Saraste… - Journal of nuclear …, 2011 - Soc Nuclear Med
The novel PET flow tracer flurpiridaz F 18 shows high myocardial extraction and slow
washout. flurpiridaz F 18 PET data analysis with tracer kinetic modeling provides accurate …

Added value of myocardial blood flow using 18F-flurpiridaz PET to diagnose coronary artery disease: The flurpiridaz 301 trial

JB Moody, A Poitrasson-Riviere, T Hagio… - Journal of Nuclear …, 2021 - Elsevier
Background 18 F-Flurpiridaz is a promising investigational radiotracer for PET myocardial
perfusion imaging with favorable properties for quantification of myocardial blood flow …

Impact of the kinetic model on diagnostic accuracy of MBF and MFR for coronary artery disease assessment using 18F-flurpiridaz PET

J Moody, A Poitrasson-Riviere, T Hagio, J Renaud… - 2020 - Soc Nuclear Med
655 Objectives: 18 F-Flurpiridaz (FPZ) is a novel radiotracer for myocardial perfusion PET
currently undergoing late stage clinical trials [1-3]. We have recently demonstrated the …

Streamlined quantification of absolute MBF at rest and stress with flurpiridaz F-18 injection PET in normal subjects and patients with coronary artery disease (CAD)

SC Huang, M Dahlbom, J Maddahi, D Truong… - 2011 - Soc Nuclear Med
1114 Objectives Flurpiridaz F-18 is a new PET myocardial perfusion tracer that is currently
undergoing clinical evaluation. We investigated the feasibility of streamlined quantification of …

Absolute quantitation of myocardial blood flow in human subjects with or without myocardial ischemia using dynamic flurpiridaz F 18 PET

RRS Packard, SC Huang, M Dahlbom… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Absolute quantitation of myocardial blood flow (MBF) by PET is an established method of
analyzing coronary artery disease (CAD) but subject to the various shortcomings of …

Single-scan rest/stress imaging with [18F] flurpiridaz: demonstration in a porcine model

N Guehl, M Normandin, D Wooten, G Rozen, A Sitek… - 2015 - Soc Nuclear Med
516 Objectives New 18 F-labeled myocardial blood flow (MBF) agents are becoming
available but the~ 2 hour half-life of 18 F complicates clinical application for rest/stress …

Optimization of imaging protocols for myocardial blood flow (MBF) quantification with 18F-flurpiridaz PET

K Wiyaporn, C Tocharoenchai, P Pusuwan, T Higuchi… - Physica Medica, 2017 - Elsevier
The new PET tracer, 18 F-flurpiridaz, with high myocardial extraction allows quantitative
myocardial blood flow (MBF) estimation from dynamic PET data and tracer kinetic modeling …

Improved Myocardial Blood Flow Estimation with Residual Activity and Motion Correction in 18F-flurpiridaz PET myocardial perfusion imaging

Y Otaki, S Van Kriekinge, CC Wei, P Kavanagh… - 2021 - Soc Nuclear Med
22 Background: 18F-flurpiridaz is a promising PET agent for myocardial perfusion imaging
(MPI), but with the long half-life attention needs to be paid to the rest/stress imaging due to …

Evolving Role of 18F-Flurpiridaz in Myocardial Perfusion Imaging

HC Lau, SJ Ng, V Kim, ME Revheim, T Werner, A Alavi… - 2023 - Soc Nuclear Med
P1072 Introduction: Coronary artery disease (CAD) is the leading cause of morbidity and
mortality worldwide; however, non-invasive assessment of CAD still remains a challenging …