Preparation of isovolumic retrograde blood-perfused rabbit hearts was similar to that
previously reported (12, 13). Briefly, after administration of 10 mg of sodium heparin and 200 …

METhODS Surgeryand Perfusion Isolated, isovolumically-contractingrabbit hearts were per
fused using established methods (2). Male New Zealand white rabbits (1.5 — 2.5 kg) were …

Radiopharmaceutical Preparation Technetium-99m-teboroxime was prepared as previously
de scribed (11). Thallium-201 was obtained from Dupont. The@ Tc was produced by …

Surgery and perfusion. An isolated, isovolumetrically-con tracting rabbit heart preparation,
utilizing methods previously describedin detail (7-9), wasusedforallexperiments. Briefly …

METHODS Open-Chested Heart Preparation Ten mongrel dogs of both sexes weighing
12— 25kg were anesthetized with iv pentobarbital (30 mg/kg). Each dog was intubated and …

The effects of metabolic inhibition on the uptake of 99mTc-teboroxime were assessed in
cultured myocardial cells and compared with 201Tl and 99mTc-sestamibi. Metabolic …

MATERIALSAND METHODS Two groups of three rabbits each, weighing 2 kg, were injected
with either 25@@ Ciof thallium-201@ or 25@ Ciof thallium-20i with 0.7 mEq/kg sodium …

The transcapillary exchange of a new class of 99mTc-labeled compounds (BATO) were
compared to 201Tl in isolated, blood perfused rabbit hearts. During variable blood flow (0.15 …

Hexakis (2-methoxy ¡ sobutylisonitrile) technetium-99m ([" TcJMIBI), a new tracer of
myocardial blood flow, was compared with 201TICI in cultures of myocardial cells of …

Technetium-99m Q12 and 99m Tc-sestamibi are cationic lipophilic myocardial perfusion
imaging tracers. Because myocardium in areas of ischemia becomes acidotic, experiments …