First-in-humans application of 161Tb: a feasibility study using 161Tb-DOTATOC

RP Baum, A Singh, HR Kulkarni… - Journal of Nuclear …, 2021 - Soc Nuclear Med
161Tb has decay properties similar to those of 177Lu but, additionally, emits a substantial
number of conversion and Auger electrons. The aim of this study was to apply 161Tb in a …

161Tb-DOTATOC production using a fully automated disposable cassette system: A first step toward the introduction of 161Tb into the clinic

C Favaretto, PV Grundler, Z Talip… - Journal of Nuclear …, 2023 - Soc Nuclear Med
161Tb is an interesting radionuclide for application in the treatment of neuroendocrine
neoplasms' small metastases and single cancer cells because of its conversion and Auger …

The low-energy β− and electron emitter 161Tb as an alternative to 177Lu for targeted radionuclide therapy

S Lehenberger, C Barkhausen, S Cohrs… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: The low-energy β− emitter 161Tb is very similar to 177Lu with respect to
half-life, beta energy and chemical properties. However, 161Tb also emits a significant …

A comparison of 111In-DOTATOC and 111In-DOTATATE: biodistribution and dosimetry in the same patients with metastatic neuroendocrine tumours

F Forrer, H Uusijärvi, C Waldherr, M Cremonesi… - European journal of …, 2004 - Springer
Abstract [Yttrium-90-DOTA-Tyr 3]-octreotide (DOTATOC) and [177 Lu-DOTA-Tyr 3-Thr 8]-
octreotide (DOTATATE) are used for peptide receptor-mediated radionuclide therapy …

[HTML][HTML] Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

C Favaretto, Z Talip, F Borgna, PV Grundler… - EJNMMI …, 2021 - Springer
Abstract Background Terbium-155 [T 1/2= 5.32 d, Eγ= 87 keV (32%) 105 keV (25%)] is an
interesting radionuclide suitable for single photon emission computed tomography (SPECT) …

[HTML][HTML] Preclinical in vivo application of 152Tb-DOTANOC: a radiolanthanide for PET imaging

C Müller, C Vermeulen, K Johnston, U Köster… - EJNMMI research, 2016 - Springer
Background Terbium has attracted the attention of researchers and physicians due to the
existence of four medically interesting radionuclides, potentially useful for SPECT and PET …

Optimal buffer choice of the radiosynthesis of 68Ga–Dotatoc for clinical application

M Bauwens, R Chekol, H Vanbilloen… - Nuclear medicine …, 2010 - journals.lww.com
Objectives 68 Ga–Dotatoc has become the PET radiopharmaceutical of choice for the
diagnosis and treatment follow-up of neuroendocrine tumours. 68 Ga–Dotatoc is prepared …

Dosimetric analyses of kidneys, liver, spleen, pituitary gland, and neuroendocrine tumors of patients treated with 177Lu-DOTATATE

SK Gupta, S Singla, P Thakral, C Bal - Clinical nuclear medicine, 2013 - journals.lww.com
Objectives The aim of this work was to calculate the radiation absorbed dose to kidneys,
liver, spleen, pituitary gland, and neuroendocrine tumors (NETs) of patients treated with 177 …

Comparison of the pharmacokinetics of 68Ga-DOTATOC and [18F]FDG in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy

S Koukouraki, LG Strauss, V Georgoulias… - European journal of …, 2006 - Springer
Purpose The purpose of this study was to evaluate and compare, by means of dynamic PET,
the pharmacokinetics of 68 Ga-DOTATOC, a tracer which reflects the expression of …

First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced 44Sc-DOTATOC: A Proof-of-Concept Study

A Singh, NP van der Meulen, C Müller… - Cancer Biotherapy …, 2017 - liebertpub.com
Abstract 44Sc is a promising positron emission tomography (PET) radionuclide (T1/2= 4.04
hours, Eβ+ average= 632 keV) and can be made available, using a cyclotron production …