Subtractionof a nonspecificradionudideis frequentlyusedto enhancevisualizationof tumors
imaged by radiolabeled monoclonal antibodies. Determining the optimal amount of the …

The low target-to-background ratio of radiolabelled antibodies often necessitates the use of
a subtraction technique to enhance areas of tumour uptake. However, interpretation of the …

A common procedure to enhance the localization of a poorly localized radiopharmaceutical
is to mimic and subtract its undesirable component with a second radionuclide of a different …

At a recent CRC-sponsored meeting to discuss the use of monoclonal antibodies, it was
noted that many of the tumours actually visualised by radioimmunoscintigraphy contained …

Quantitative autoradiography can be an important element in calculating dose patterns
delivered to tumors and normal tissues of animals injected with radiolabeled antibodies. In …

A variety of tumours can be detected with radiolabelled antibodies and a gamma camera.
Unfortunately, Low count rates and poor contrast combine to produce images that are often …

[en] The ability to image tumor using radiolabeled monoclonal antibody products has been
widely demonstrated. The questions of safety and efficacy remain open and require further …

External in vivo imaging of tumors with radioactively labeled antibodies to tumor-associated
antigens requires processing to remove interfering nontarget radioactivity. Processing …

This paper is devoted to the application of the Image Subtraction Technique to
immunoscintigraphy. It is technical, because, although based on simple principles, this …

Although there are many factors that influence the ability of a radiolabeled antibody to image
tumors by external scintigraphy, perhaps the most problematic has been the ability to …