Peptide-targeted radionuclide therapy (PTRT) using Lu-177 FAP-2286 in diverse adenocarcinomas: feasibility, biodistribution and preliminary dosimetry in a first-in …
R Baum, M Chantadisai, C Smerling, C Schuchardt… - 2020 - Soc Nuclear Med
633 Objectives: Fibroblast Activation Protein FAP-2286 is the first compound with high tumor
uptake, long tumor retention as well as low background activity as shown in in preclinical …
uptake, long tumor retention as well as low background activity as shown in in preclinical …
Feasibility, biodistribution, and preliminary dosimetry in peptide-targeted radionuclide therapy of diverse adenocarcinomas using 177Lu-FAP-2286: first-in-humans …
RP Baum, C Schuchardt, A Singh… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein (FAP) is a promising target for diagnosis and therapy of
numerous malignant tumors. FAP-2286 is the conjugate of a FAP-binding peptide, which …
numerous malignant tumors. FAP-2286 is the conjugate of a FAP-binding peptide, which …
177Lu-FAP-2286 in patients with advanced or metastatic solid tumors: Initial data from a phase 1/2 study investigating safety, pharmacokinetics, dosimetry, and …
2271 Introduction: Fibroblast activation protein (FAP) is a membrane protease that is highly
expressed by cancer-associated fibroblasts in many epithelial tumors and by tumor cells in …
expressed by cancer-associated fibroblasts in many epithelial tumors and by tumor cells in …
571P Preclinical evaluation of FAP-2286, a peptide-targeted radionuclide therapy (PTRT) to fibroblast activation protein alpha (FAP)
D Zboralski, F Osterkamp, AD Simmons… - Annals of …, 2020 - annalsofoncology.org
Background FAP is a membrane bound protease that has limited expression in normal adult
tissues but is highly expressed on cancer associated fibroblasts (CAFs), which are abundant …
tissues but is highly expressed on cancer associated fibroblasts (CAFs), which are abundant …
Abstract LBA032: Pan-cancer analysis of fibroblast activation protein alpha (FAP) expression to guide tumor selection for the peptide-targeted radionuclide therapy …
TT Kwan, M Nguyen, D Zboralski, A Schumann… - Molecular Cancer …, 2021 - AACR
Background: FAP is a membrane-bound protease with limited expression in normal tissues
but high expression on cancer-associated fibroblasts abundant in the stroma of most tumors …
but high expression on cancer-associated fibroblasts abundant in the stroma of most tumors …
Peptide Targeted Radiotherapy using cancer-associated fibroblasts as target in solid tumors: first clinical experience with the 177Lu-, 225Ac-and 90Y-labeled peptide …
RP Baum, L Greifenstein, C Kramer, A Klega… - 2022 - Soc Nuclear Med
2269 Introduction: We recently published our first clinical experience using 177 Lu-FAP-
2286, a peptide binding to FAP expressed on cancer-associated fibroblasts (CAF) in the …
2286, a peptide binding to FAP expressed on cancer-associated fibroblasts (CAF) in the …
[PDF][PDF] 3BP-3940, a highly potent FAP-targeting peptide for theranostics-production, validation and first in human experience with Ga-68 and Lu-177
L Greifenstein, A Gunkel, A Hoehne, F Osterkamp… - Iscience, 2023 - cell.com
Hardly any new tracers attracted more attention in nuclear medicine in the last couple of
years than radiolabeled fibroblast activation protein inhibitors (FAPi's). Molecules targeting …
years than radiolabeled fibroblast activation protein inhibitors (FAPi's). Molecules targeting …
Abstract CT251: LuMIERE: A phase 1/2 study investigating safety, pharmacokinetics, dosimetry, and preliminary antitumor activity of 177Lu-FAP-2286 in patients with …
J McConathy, M Dhawan, AH Goenka, EA Lim… - Cancer Research, 2022 - AACR
Background: Fibroblast activation protein (FAP) is a membrane-bound protease that is
highly expressed on the surface of cancer-associated fibroblasts (CAFs) present in the tumor …
highly expressed on the surface of cancer-associated fibroblasts (CAFs) present in the tumor …
Radiolabeling and stability of FAP-seeking radiopharmaceuticals for radio-molecular imaging and therapy
D Mueller, A Fuchs, Y Leshch, P Schulze, A Singh… - 2020 - Soc Nuclear Med
1129 Introduction: Cancer-associated fibroblast activation protein is a high potential target
for radio-molecular imaging and therapy. This protein is expressed on cancer-associated …
for radio-molecular imaging and therapy. This protein is expressed on cancer-associated …
[177Lu]Lu-FAP-2286 therapy in a case of right lung squamous cell carcinoma with systemic metastases
Z Rao, Y Zhang, L Liu, M Wang, C Zhang - European Journal of Nuclear …, 2023 - Springer
Fibroblast activation protein (FAP), as a type-II transmembrane overexpressed in cancer-
associated fibroblasts, is a promising target for diagnosis and therapy of numerous …
associated fibroblasts, is a promising target for diagnosis and therapy of numerous …