Radioimmunotherapy of a human lung cancer xenograft with monoclonal antibody RS7: evaluation of 177Lu and comparison of its efficacy with that of 90Y and …

R Stein, SV Govindan, S Chen, L Reed… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Tumor targeting and therapeutic efficacy of 177Lu-labeled monoclonal antibody (mAb) RS7
(antiepithelial glycoprotein-1) was evaluated in a human nonsmall cell lung carcinoma …

Advantage of yttrium‐90‐labeled over iodine‐131‐labeled monoclonal antibodies in the treatment of a human lung carcinoma xenograft

R Stein, S Chen, S Haim… - … International Journal of …, 1997 - Wiley Online Library
BACKGROUND The purpose of this investigation was to compare the therapeutic
effectiveness of yttrium‐90 (90Y)‐labeled monoclonal antibodies (MoAbs) with iodine‐131 …

Successful therapy of a human lung cancer xenograft using MAb RS7 labeled with residualizing radioiodine

R Stein, SV Govindan, S Chen, L Reed… - Critical reviews in …, 2001 - Elsevier
We have recently reported that a radioiodinated, DTPA-appended peptide, designated IMP-
R1, is a residualizing iodine label that overcomes many of the limitations that have impeded …

Comparative biodistribution and radioimmunotherapy of monoclonal antibody rs7 and its f(ab′)2 in nude mice bearing human tumor xenografts

R Stein, R Blumenthal, RM Sharkey, DM Goldenberg - Cancer, 1994 - Wiley Online Library
Background. RS7 is a murine monoclonal antibody immunoglobulin G1 with pancarcinoma
reactivity, which was raised against human squamous cell carcinoma of the lung. To …

186Re Radioimmunotherapy of Small Cell Lung Carcinoma Xenografts in Nude Mice

PL Beaumier, P Venkatesan, JL Vanderheyden… - Cancer Research, 1991 - AACR
A 186Re-labeled monoclonal antibody (MAb), NR-LU-10, was used for the
radioimmunotherapy of a subcutaneous human small cell lung carcinoma xenograft, SHT-1 …

Improved iodine radiolabels for monoclonal antibody therapy

R Stein, SV Govindan, MJ Mattes, S Chen, L Reed… - Cancer Research, 2003 - AACR
A major disadvantage of 131iodine (I)-labeled monoclonal antibodies (MAbs) for
radioimmunotherapyhas been the rapid diffusion of iodotyrosine from target cells …

Targeting human cancer xenografts with monoclonal antibodies labeled using radioiodinated, diethylenetriaminepentaacetic acid-appended peptides

R Stein, SV Govindan, MJ Mattes, LB Shih… - Clinical Cancer …, 1999 - AACR
A new nonmetabolizable peptide approach to the production of residualizing radioiodine
was evaluated in nude mice bearing xenografts of human lung adenocarcinoma (Calu-3) …

Biodistributions of 177Lu- and 111In-Labeled 7E11 Antibodies to Prostate-Specific Membrane Antigen in Xenograft Model of Prostate Cancer and Potential Use of 111In-7E11 …

MH Pan, DW Gao, J Feng, J He, Y Seo… - Molecular imaging and …, 2009 - Springer
Introduction Prostate-specific membrane antigen is a transmembrane glycoprotein highly
expressed in many prostate cancers and can be targeted with radiolabeled antibodies for …

[PDF][PDF] Clinical experience with rhenium-186-labeled monoclonal antibodies for radioimmunotherapy: results of phase I trials

HB Breitz, PL Weiden, JL Vanderheyden… - Journal of Nuclear …, 1992 - Soc Nuclear Med
Therapy (no. of pts): None or antimetabo 6 17lites onlyRadiation ±antime 3
6tabolitesIntensive chemo ±6 8radiation and MTD of) ssRe@ labeledintact NR-LU-10, and …

Relative therapeutic efficacy of 125I-and 131I-labeled monoclonal antibody A33 in a human colon cancer xenograft

EC Barendswaard, JL Humm… - Journal of Nuclear …, 2001 - Soc Nuclear Med
A33, a monoclonal antibody that targets colon carcinomas, was labeled with 125I or 131I
and the relative therapeutic efficacy of the 2 radiolabeled species was compared in a human …